Tchem ORAI1 Calcium release-activated calcium channel protein 1

Protein Summary

Description

Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores and channel activation by the Ca(2+) sensor, STIM1 (PubMed:16582901, PubMed:16645049, PubMed:16733527, PubMed:16766533, PubMed:16807233, PubMed:19249086, PubMed:23307288, PubMed:24351972, PubMed:24591628, PubMed:28219928). CRAC channels are the main pathway for Ca(2+) influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT (PubMed:16582901). The protein encoded by this gene is a membrane calcium channel subunit that is activated by the calcium sensor STIM1 when calcium stores are depleted. This type of channel is the primary way for calcium influx into T-cells. Defects in this gene are a cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 1 (IDTICED1). [provided by RefSeq, Sep 2011]

Uniprot Accession IDs

• Q96D31
• Q3MHV3
• Q6DHX2
• Q96BP7
• Q96K71

Gene Name

• ORAI1

Ensembl ID

• ENST00000617316
• ENSP00000482568
• ENSG00000276045

Symbol

• CRACM1
• TMEM142A
• IMD9
• TAM2
• ORAT1
• CRACM1
• TMEM142A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.91
molecular function	0.84
transcription factor	0.79
biological term	0.65
tissue sample	0.6

Protein Classes

DTO Classes

Protein / Ion Channel / Calcium Release-activated Calcium (Crac) Channel (Crac-c) Family / Calcium Release-activated Calcium Channel Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 709.73   (req: < 5)

Gene RIFs: 359   (req: <= 3)

Antibodies: 449   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 709.73   (req: >= 5)

Gene RIFs: 359   (req: > 3)

Antibodies: 449   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 16

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0