Property Summary

NCBI Gene PubMed Count 20
PubMed Score 27.57
PubTator Score 8.88

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (1)

Disease Target Count P-value
malignant mesothelioma 3163 2.38434052490402E-7
ovarian cancer 8492 2.37908119128425E-6
Amyotrophic Lateral Sclerosis 432 2.54832878795887E-6
osteosarcoma 7933 1.7007187859754E-5
medulloblastoma, large-cell 6234 4.58640078209839E-5
group 4 medulloblastoma 1875 1.19508122455229E-4
tuberculosis and treatment for 6 months 686 0.00103929715271353
atypical teratoid / rhabdoid tumor 4369 0.00124883737225645
oligodendroglioma 2849 0.00799488336491733
psoriasis 6685 0.0240360939389496
aldosterone-producing adenoma 664 0.0306147135441483

Expression

  Differential Expression (11)

Synonym

Accession Q96CW5 O43631 O60852 O60853 Q5T8L2 Q7Z4K1 Q96I79 GCP-3
Symbols 104p
GCP3
Spc98
SPBC98
Spc98p
Grip104

Gene

  Ortholog (15)

Gene RIF (5)

PMID Text
26079448 This study demonstrated that Overexpression and Nucleolar Localization gcp3 in glioblastoma.
23886939 Authors show genetically that GCP3/Spc98 function is fully conserved with Alp6 across species but that functional differences exist between GCP2/Spc97 and Alp4.
20858683 Observational study, meta-analysis, and genome-wide association study of gene-disease association. (HuGE Navigator)
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
19299467 Stability of the small gamma-tubulin complex (gamma tubulin/GCP2/GCP3) requires HCA66, a protein of the centrosome and the nucleolus.

AA Sequence

MATPDQKSPNVLLQNLCCRILGRSEADVAQQFQYAVRVIGSNFAPTVERDEFLVAEKIKKELIRQRREAD      1 - 70
AALFSELHRKLHSQGVLKNKWSILYLLLSLSEDPRRQPSKVSSYATLFAQALPRDAHSTPYYYARPQTLP     71 - 140
LSYQDRSAQSAQSSGSVGSSGISSIGLCALSGPAPAPQSLLPGQSNQAPGVGDCLRQQLGSRLAWTLTAN    141 - 210
QPSSQATTSKGVPSAVSRNMTRSRREGDTGGTMEITEAALVRDILYVFQGIDGKNIKMNNTENCYKVEGK    211 - 280
ANLSRSLRDTAVRLSELGWLHNKIRRYTDQRSLDRSFGLVGQSFCAALHQELREYYRLLSVLHSQLQLED    281 - 350
DQGVNLGLESSLTLRRLLVWTYDPKIRLKTLAALVDHCQGRKGGELASAVHAYTKTGDPYMRSLVQHILS    351 - 420
LVSHPVLSFLYRWIYDGELEDTYHEFFVASDPTVKTDRLWHDKYTLRKSMIPSFMTMDQSRKVLLIGKSI    421 - 490
NFLHQVCHDQTPTTKMIAVTKSAESPQDAADLFTDLENAFQGKIDAAYFETSKYLLDVLNKKYSLLDHMQ    491 - 560
AMRRYLLLGQGDFIRHLMDLLKPELVRPATTLYQHNLTGILETAVRATNAQFDSPEILRRLDVRLLEVSP    561 - 630
GDTGWDVFSLDYHVDGPIATVFTRECMSHYLRVFNFLWRAKRMEYILTDIRKGHMCNAKLLRNMPEFSGV    631 - 700
LHQCHILASEMVHFIHQMQYYITFEVLECSWDELWNKVQQAQDLDHIIAAHEVFLDTIISRCLLDSDSRA    701 - 770
LLNQLRAVFDQIIELQNAQDAIYRAALEELQRRLQFEEKKKQREIEGQWGVTAAEEEEENKRIGEFKESI    771 - 840
PKMCSQLRILTHFYQGIVQQFLVLLTTSSDESLRFLSFRLDFNEHYKAREPRLRVSLGTRGRRSSHT       841 - 907
//

Text Mined References (27)

PMID Year Title
26079448 2015 Overexpression and Nucleolar Localization of ?-Tubulin Small Complex Proteins GCP2 and GCP3 in Glioblastoma.
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
23886939 2013 Functional replacement of fission yeast ?-tubulin small complex proteins Alp4 and Alp6 by human GCP2 and GCP3.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
22814378 2012 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
21399614 2011 Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods.
21269460 2011 Initial characterization of the human central proteome.
20858683 2010 Common variants at 10 genomic loci influence hemoglobin A?(C) levels via glycemic and nonglycemic pathways.
20379614 Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
19946888 2010 Defining the membrane proteome of NK cells.
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