| Tdark | GRIP and coiled-coil domain-containing protein 1 |
Probably involved in maintaining Golgi structure.
The protein encoded by this gene is a peripheral membrane protein. It is sensitive to brefeldin A. This encoded protein contains a GRIP domain which is thought to be used in targeting. It may play a role in the organization of trans-Golgi network subcompartment involved with membrane transport. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a peripheral membrane protein. It is sensitive to brefeldin A. This encoded protein contains a GRIP domain which is thought to be used in targeting. It may play a role in the organization of trans-Golgi network subcompartment involved with membrane transport. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count |
|---|---|
| Cocaine-Related Disorders | 88 |
| Marijuana Abuse | 8 |
| Phencyclidine Abuse | 5 |
| Disease | Target Count | P-value |
|---|---|---|
| group 3 medulloblastoma | 2254 | 2.05793382056037E-4 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Type 2 diabetes mellitus | 192 | 0.0 | 2.0 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Secretory diarrhea | 6 | 3.635 | 1.8 |
| Species | Source |
|---|---|
| Chimp | OMA EggNOG |
| Macaque | OMA EggNOG Inparanoid |
| Mouse | OMA EggNOG Inparanoid |
| Rat | OMA EggNOG Inparanoid |
| Dog | OMA EggNOG Inparanoid |
| Cow | OMA EggNOG Inparanoid |
| Opossum | OMA EggNOG Inparanoid |
| Platypus | OMA EggNOG |
| Anole lizard | OMA EggNOG Inparanoid |
| Xenopus | OMA EggNOG Inparanoid |
| PMID | Text |
|---|---|
| 17914056 | identified an essential role for GCC88 in the localization of TGN fusion machinery for transport from early endosomes to the trans-Golgi network |
| 15654769 | The ability of the four mammalian GRIP domain proteins, p230, golgin-97, GCC88, and GCC185 to interact is reported. |
| 12446665 | targeting to subcompartments of trans-Golgi network by GRIP domain |
MEKFGMNFGGGPSKKDLLETIETQKKQLLQYQARLKDVVRAYKSLLKEKEALEASIKVLSVSHEADVGLA 1 - 70 GVQLPGLTFPDSVDDRCSTHSEDSTGTATSLDTAASLTSTKGEFGVEDDRPARGPPPPKSEEASWSESGV 71 - 140 SSSSGDGPFAGGEVDKRLHQLKTQLATLTSSLATVTQEKSRMEASYLADKKKMKQDLEDASNKAEEERAR 141 - 210 LEGELKGLQEQIAETKARLITQQHDRAQEQSDHALMLRELQKLLQEERTQRQDLELRLEETREALAGRAY 211 - 280 AAEQMEGFELQTKQLTREVEELKSELQAIRDEKNQPDPRLQELQEEAARLKSHFQAQLQQEMRKTALAED 281 - 350 QLRQQSQVEEQRVAALENQISEVSELLGTYEKAKQKDQLAIQKLKERILQLDLENKTLALAASSRSPLDS 351 - 420 HGEESSLDVNVLKDKMEKLKRLLQVAARKSQVTLDVEKLCDLEIMPSSEAADGEKATALYYQQELKQLKE 421 - 490 EFERYKMRAQVVLKSKNTKDGNLGKELEAAQEQLAELKEKYISLRLSCEELEHQHQQEADDWKQELARLQ 491 - 560 QLHRQELERCQLDFRDRTLKLEEELHKQRDRALAVLTEKDLELEQLRSVALASGLPGRRSPVGGGGPGDP 561 - 630 ADTSSSDSLTQALQLAAANEPTFFLYAEQLARKEVEITSLRKQKHRLEVEVHQLQDRLLEEGERHREEVA 631 - 700 ALQSHIEKNIRDQSREGANLEYLKNIIYRFLTLPDSLGRQQTLTAILTILHFSPEEKQVIMRLPTSASWW 701 - 770 PSGKR 771 - 775 //
| PMID | Year | Title |
|---|---|---|
| 25416956 | 2014 | A proteome-scale map of the human interactome network. |
| 25317111 | 2014 | Genome-wide association study of medication adherence in chronic diseases in the korean population. |
| 22158537 | 2011 | Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians. |
| 21516116 | 2011 | Next-generation sequencing to generate interactome datasets. |
| 18029348 | 2008 | Toward a confocal subcellular atlas of the human proteome. |
| 17914056 | 2007 | The golgin GCC88 is required for efficient retrograde transport of cargo from the early endosomes to the trans-Golgi network. |
| 16713569 | 2006 | A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |
| 16189514 | 2005 | Towards a proteome-scale map of the human protein-protein interaction network. |
| 15654769 | 2005 | The trans-Golgi network GRIP-domain proteins form alpha-helical homodimers. |
| 15489334 | 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
| More... |
