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Tdark GRIP and coiled-coil domain-containing protein 1

Probably involved in maintaining Golgi structure.

The protein encoded by this gene is a peripheral membrane protein. It is sensitive to brefeldin A. This encoded protein contains a GRIP domain which is thought to be used in targeting. It may play a role in the organization of trans-Golgi network subcompartment involved with membrane transport. [provided by RefSeq, Jul 2008]

 Comments

Property Summary

NCBI Gene PubMed Count 15
PubMed Score 4.69
PubTator Score 12.43

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Relevance (6)

Disease Z-score Confidence
Secretory diarrhea 6 3.635 1.8
Cocaine-Related Disorders 88
Marijuana Abuse 8
Phencyclidine Abuse 5
Type 2 diabetes mellitus 189 2.0
group 3 medulloblastoma 2,254

Expression

  Differential Expression (1)

Disease log2 FC p
group 3 medulloblastoma 1.200 0.000

Synonym

Accession Q96CN9 Q9H6N7
Symbols GCC1P
GCC88

Gene

GCC1

 GO Component (5)

 GO Process (1)

 Compartment GO Term (26)

See all...

Pathway (5)

 UniProt Keyword (7)

Gene RIF (3)

PMID Text
17914056 identified an essential role for GCC88 in the localization of TGN fusion machinery for transport from early endosomes to the trans-Golgi network
15654769 The ability of the four mammalian GRIP domain proteins, p230, golgin-97, GCC88, and GCC185 to interact is reported.
12446665 targeting to subcompartments of trans-Golgi network by GRIP domain

AA Sequence 

MEKFGMNFGGGPSKKDLLETIETQKKQLLQYQARLKDVVRAYKSLLKEKEALEASIKVLSVSHEADVGLA      1 - 70
GVQLPGLTFPDSVDDRCSTHSEDSTGTATSLDTAASLTSTKGEFGVEDDRPARGPPPPKSEEASWSESGV     71 - 140
SSSSGDGPFAGGEVDKRLHQLKTQLATLTSSLATVTQEKSRMEASYLADKKKMKQDLEDASNKAEEERAR    141 - 210
LEGELKGLQEQIAETKARLITQQHDRAQEQSDHALMLRELQKLLQEERTQRQDLELRLEETREALAGRAY    211 - 280
AAEQMEGFELQTKQLTREVEELKSELQAIRDEKNQPDPRLQELQEEAARLKSHFQAQLQQEMRKTALAED    281 - 350
QLRQQSQVEEQRVAALENQISEVSELLGTYEKAKQKDQLAIQKLKERILQLDLENKTLALAASSRSPLDS    351 - 420
HGEESSLDVNVLKDKMEKLKRLLQVAARKSQVTLDVEKLCDLEIMPSSEAADGEKATALYYQQELKQLKE    421 - 490
EFERYKMRAQVVLKSKNTKDGNLGKELEAAQEQLAELKEKYISLRLSCEELEHQHQQEADDWKQELARLQ    491 - 560
QLHRQELERCQLDFRDRTLKLEEELHKQRDRALAVLTEKDLELEQLRSVALASGLPGRRSPVGGGGPGDP    561 - 630
ADTSSSDSLTQALQLAAANEPTFFLYAEQLARKEVEITSLRKQKHRLEVEVHQLQDRLLEEGERHREEVA    631 - 700
ALQSHIEKNIRDQSREGANLEYLKNIIYRFLTLPDSLGRQQTLTAILTILHFSPEEKQVIMRLPTSASWW    701 - 770
PSGKR                                                                     771 - 775
//

Text Mined References (15)

PMID Year Title
25416956 2014 A proteome-scale map of the human interactome network.
25317111 2014 Genome-wide association study of medication adherence in chronic diseases in the korean population.
22158537 2011 Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians.
21516116 2011 Next-generation sequencing to generate interactome datasets.
18029348 2008 Toward a confocal subcellular atlas of the human proteome.
17914056 2007 The golgin GCC88 is required for efficient retrograde transport of cargo from the early endosomes to the trans-Golgi network.
16713569 2006 A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.
16189514 2005 Towards a proteome-scale map of the human protein-protein interaction network.
15654769 2005 The trans-Golgi network GRIP-domain proteins form alpha-helical homodimers.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
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