Tbio CTHRC1 Collagen triple helix repeat-containing protein 1

Protein Summary

Description

May act as a negative regulator of collagen matrix deposition. This locus encodes a protein that may play a role in the cellular response to arterial injury through involvement in vascular remodeling. Mutations at this locus have been associated with Barrett esophagus and esophageal adenocarcinoma. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2012]

Uniprot Accession IDs

• Q96CG8
• G3V141
• Q6UW91
• Q8IX63

Gene Name

• CTHRC1

Ensembl ID

• ENST00000330295
• ENSP00000330523
• ENSG00000164932
• ENST00000520337
• ENSP00000430550

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.99
PubMedID	0.93
histone modification site profile	0.67
small molecule perturbation	0.66
tissue sample	0.6

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Oxygenase / Collagen Triple Helix Repeat-containing Protein 1

DTO Classes

Protein / Enzyme / Oxidoreductase / Oxygenase / Collagen Triple Helix Repeat-containing Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 142.11   (req: < 5)

Gene RIFs: 82   (req: <= 3)

Antibodies: 260   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 142.11   (req: >= 5)

Gene RIFs: 82   (req: > 3)

Antibodies: 260   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0