Tbio ATG2B Autophagy-related protein 2 homolog B

Protein Summary

Description

Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion. This gene encodes a protein required for autophagy. The encoded protein is involved in autophagosome formation. A germline duplication of a region that includes this gene is associated with predisposition to myeloid malignancies. [provided by RefSeq, Jul 2016]

Uniprot Accession IDs

• Q96BY7
• Q6ZRE7
• Q96DQ3
• Q9NW80

Gene Name

• ATG2B

Ensembl ID

• ENST00000359933
• ENSP00000353010
• ENSG00000066739

Symbol

• C14orf103
• C14orf103

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.9
drug perturbation	0.71
microRNA	0.67
tissue sample	0.66
disease perturbation	0.62

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.05   (req: < 5)

Gene RIFs: 23   (req: <= 3)

Antibodies: 130   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.05   (req: >= 5)

Gene RIFs: 23   (req: > 3)

Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0