Tchem SGK3 Serine/threonine-protein kinase Sgk3

Protein Summary

Description

Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, proliferation, survival and migration. Up-regulates Na(+) channels: SCNN1A/ENAC and SCN5A, K(+) channels: KCNA3/KV1.3, KCNE1, KCNQ1 and KCNH2/HERG, epithelial Ca(2+) channels: TRPV5 and TRPV6, chloride channel: BSND, creatine transporter: SLC6A8, Na(+)/dicarboxylate cotransporter: SLC13A2/NADC1, Na(+)-dependent phosphate cotransporter: SLC34A2/NAPI-2B, amino acid transporters: SLC1A5/ASCT2 and SLC6A19, glutamate transporters: SLC1A3/EAAT1, SLC1A6/EAAT4 and SLC1A7/EAAT5, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase. Plays a role in the regulation of renal tubular phosphate transport and bone density. Phosphorylates NEDD4L and GSK3B. Positively regulates ER transcription activity through phosphorylation of FLII. Negatively regulates the function of ITCH/AIP4 via its phosphorylation and thereby prevents CXCR4 from being efficiently sorted to lysosomes. This locus represents naturally occurring read-through transcription between the neighboring putative uncharacterized protein C8orf44 (GeneID 56260) and serine/threonine-protein kinase Sgk3 (GeneID 23678) genes on chromosome 8. The read-through transcript produces a protein that shares sequence identity with the downstream gene product. [provided by RefSeq, Feb 2011]

Uniprot Accession IDs

• Q96BR1
• A8K5W3
• B3KQC2
• Q9P1Q7
• Q9UKG5

Gene Name

• SGK3

Ensembl ID

• ENST00000345714
• ENSP00000331816
• ENSG00000104205
• ENST00000396596
• ENSP00000379842
• ENST00000519289
• ENSP00000429022
• ENST00000520976
• ENSP00000430691
• ENST00000521198
• ENSP00000430463
• ENST00000522398
• ENSP00000430256

Symbol

• CISK
• SGKL

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.91
interacting protein	0.86
transcription factor	0.77
PubMedID	0.73
microRNA	0.71

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Protein Kinase / Non-receptor Serine/threonine Protein Kinase / Serine/threonine-protein Kinase Sgk3

Protein / Transfer/carrier Protein / Serine/threonine-protein Kinase Sgk3

Protein / Calcium-binding Protein / Intracellular Calcium-sensing Protein / Calmodulin / Serine/threonine-protein Kinase Sgk3

Protein / Calcium-binding Protein / Annexin / Serine/threonine-protein Kinase Sgk3

DTO Classes

Protein / Kinase / Protein Kinase / Agc Group / Sgk Family / Serine/threonine-protein Kinase Sgk3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.36   (req: < 5)

Gene RIFs: 46   (req: <= 3)

Antibodies: 312   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.36   (req: >= 5)

Gene RIFs: 46   (req: > 3)

Antibodies: 312   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0