| Tbio | Engulfment and cell motility protein 3 |
Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1 (By similarity).
The protein encoded by this gene is similar to a C. elegans protein that functions in phagocytosis of apoptotic cells and in cell migration. Other members of this small family of engulfment and cell motility (ELMO) proteins have been shown to interact with the dedicator of cyto-kinesis 1 protein to promote phagocytosis and effect cell shape changes. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is similar to a C. elegans protein that functions in phagocytosis of apoptotic cells and in cell migration. Other members of this small family of engulfment and cell motility (ELMO) proteins have been shown to interact with the dedicator of cyto-kinesis 1 protein to promote phagocytosis and effect cell shape changes. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| osteosarcoma | 7950 | 4.6e-08 |
| pituitary cancer | 1972 | 2.2e-04 |
| interstitial cystitis | 2312 | 9.8e-04 |
| pancreatic ductal adenocarcinoma liver metastasis | 1962 | 9.0e-03 |
| ductal carcinoma in situ | 1745 | 1.3e-02 |
| invasive ductal carcinoma | 2951 | 4.2e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Glottis carcinoma | 2 | 4.063 | 2.0 |
| Disease | log2 FC | p |
|---|---|---|
| ductal carcinoma in situ | 1.400 | 1.3e-02 |
| interstitial cystitis | -1.700 | 9.8e-04 |
| invasive ductal carcinoma | 1.500 | 4.2e-02 |
| osteosarcoma | -2.989 | 4.6e-08 |
| pancreatic ductal adenocarcinoma liver m... | 1.130 | 9.0e-03 |
| pituitary cancer | -1.100 | 2.2e-04 |
MAPPRNVVKIAIKMRDAIPQLIQLDQAKPLAAVLKEVCDAWSLTHSERYALQFADGHRRYITENNRAEIK 1 - 70 NGSILCLSTAPDLEAEQLLGGLQSNSPEGRREALRRLVPLASDMIFAREVISRNGLQILGTIIEDGDDLG 71 - 140 EVLALSLRAFSELMEHGVVSWETLSIPFVRKVVCYVNMNLMDASVPPLALGLLESVTLSSPALGQLVKSE 141 - 210 VPLDRLLVHLQVMNQQLQTKAMALLTALLQGASPVERKHMLDYLWQRNLRQFIYKNIIHSAAPMGDEMAH 211 - 280 HLYVLQALMLGLLEPRMRTPLDPYSQEQREQLQVLRQAAFEVEGESSGAGLSADRRRSLCAREFRKLGFS 281 - 350 NSNPAQDLERVPPGLLALDNMLYFSRNAPSAYSRFVLENSSREDKHECPFARGSIQLTVLLCELLRVGEP 351 - 420 CSETAQDFSPMFFGQDQSFHELFCVGIQLLNKTWKEMRATQEDFDKVMQVVREQLARTLALKPTSLELFR 421 - 490 TKVNALTYGEVLRLRQTERLHQEGTLAPPILELREKLKPELMGLIRQQRLLRLCEGTLFRKISSRRRQDK 491 - 560 LWFCCLSPNHKLLQYGDMEEGASPPTLESLPEQLPVADMRALLTGKDCPHVREKGSGKQNKDLYELAFSI 561 - 630 SYDRGEEEAYLNFIAPSKREFYLWTDGLSALLGSPMGSEQTRLDLEQLLTMETKLRLLELENVPIPERPP 631 - 700 PVPPPPTNFNFCYDCSIAEP 701 - 720 //
