| Tbio | Engulfment and cell motility protein 3 |
Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in assocation with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1 (By similarity).
The protein encoded by this gene is similar to a C. elegans protein that functions in phagocytosis of apoptotic cells and in cell migration. Other members of this small family of engulfment and cell motility (ELMO) proteins have been shown to interact with the dedicator of cyto-kinesis 1 protein to promote phagocytosis and effect cell shape changes. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is similar to a C. elegans protein that functions in phagocytosis of apoptotic cells and in cell migration. Other members of this small family of engulfment and cell motility (ELMO) proteins have been shown to interact with the dedicator of cyto-kinesis 1 protein to promote phagocytosis and effect cell shape changes. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| osteosarcoma | 7933 | 4.59564415159625E-8 |
| interstitial cystitis | 2299 | 1.72573976583266E-5 |
| pituitary cancer | 1972 | 2.16188422833636E-4 |
| pancreatic ductal adenocarcinoma liver metastasis | 1795 | 0.00895917395917132 |
| ductal carcinoma in situ | 1745 | 0.0125993874484707 |
| invasive ductal carcinoma | 2950 | 0.0421998467286407 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Glottis carcinoma | 2 | 4.102 | 2.1 |
| Disease | log2 FC | p |
|---|---|---|
| osteosarcoma | -2.989 | 0.000 |
| pancreatic ductal adenocarcinoma liver m... | 1.130 | 0.009 |
| interstitial cystitis | -2.100 | 0.000 |
| ductal carcinoma in situ | 1.400 | 0.013 |
| invasive ductal carcinoma | 1.500 | 0.042 |
| pituitary cancer | -1.100 | 0.000 |
| Species | Source |
|---|---|
| Chimp | OMA EggNOG |
| Macaque | OMA EggNOG Inparanoid |
| Mouse | OMA EggNOG Inparanoid |
| Rat | OMA EggNOG Inparanoid |
| Dog | OMA EggNOG Inparanoid |
| Cow | OMA EggNOG Inparanoid |
| Opossum | EggNOG Inparanoid |
| Platypus | OMA EggNOG Inparanoid |
| Anole lizard | OMA EggNOG Inparanoid |
| Xenopus | OMA EggNOG Inparanoid |
| C. elegans | OMA Inparanoid |
| Fruitfly | EggNOG Inparanoid |
| PMID | Text |
|---|---|
| 26191257 | The over-expression of ELMO3 was a potential diagnostic and prognostic marker for non-small cell lung cancer. |
| 20127720 | The present study reports the first characterization of the ELMO3 promoter and suggests a significant role of CDX2 in the basal transcriptional regulation of the intestine-specific expression of ELMO3, possibly through interaction with SP1. |
MAPPRNVVKIAIKMRDAIPQLIQLDQAKPLAAVLKEVCDAWSLTHSERYALQFADGHRRYITENNRAEIK 1 - 70 NGSILCLSTAPDLEAEQLLGGLQSNSPEGRREALRRLVPLASDMIFAREVISRNGLQILGTIIEDGDDLG 71 - 140 EVLALSLRAFSELMEHGVVSWETLSIPFVRKVVCYVNMNLMDASVPPLALGLLESVTLSSPALGQLVKSE 141 - 210 VPLDRLLVHLQVMNQQLQTKAMALLTALLQGASPVERKHMLDYLWQRNLRQFIYKNIIHSAAPMGDEMAH 211 - 280 HLYVLQALMLGLLEPRMRTPLDPYSQEQREQLQVLRQAAFEVEGESSGAGLSADRRRSLCAREFRKLGFS 281 - 350 NSNPAQDLERVPPGLLALDNMLYFSRNAPSAYSRFVLENSSREDKHECPFARGSIQLTVLLCELLRVGEP 351 - 420 CSETAQDFSPMFFGQDQSFHELFCVGIQLLNKTWKEMRATQEDFDKVMQVVREQLARTLALKPTSLELFR 421 - 490 TKVNALTYGEVLRLRQTERLHQEGTLAPPILELREKLKPELMGLIRQQRLLRLCEGTLFRKISSRRRQDK 491 - 560 LWFCCLSPNHKLLQYGDMEEGASPPTLESLPEQLPVADMRALLTGKDCPHVREKGSGKQNKDLYELAFSI 561 - 630 SYDRGEEEAYLNFIAPSKREFYLWTDGLSALLGSPMGSEQTRLDLEQLLTMETKLRLLELENVPIPERPP 631 - 700 PVPPPPTNFNFCYDCSIAEP 701 - 720 //
| PMID | Year | Title |
|---|---|---|
| 26191257 | 2015 | ELMO3 is a novel biomarker for diagnosis and prognosis of non-small cell lung cancer. |
| 24567399 | 2014 | G-protein coupled receptor BAI3 promotes myoblast fusion in vertebrates. |
| 20127720 | 2010 | Control of intestinal promoter activity of the cellular migratory regulator gene ELMO3 by CDX2 and SP1. |
| 16344560 | 2006 | Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |
| 15616553 | 2004 | The sequence and analysis of duplication-rich human chromosome 16. |
| 15489334 | 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
| 14702039 | 2004 | Complete sequencing and characterization of 21,243 full-length human cDNAs. |
| 12477932 | 2002 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |
| 11595183 | 2001 | CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration. |
