Tbio NACC2 Nucleus accumbens-associated protein 2

Protein Summary

Description

Functions as a transcriptional repressor through its association with the NuRD complex. Recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53.

Uniprot Accession IDs

• Q96BF6
• NAC-2

Gene Name

• NACC2

Ensembl ID

• ENST00000277554
• ENSP00000277554
• ENSG00000148411
• ENST00000371753
• ENSP00000360818

Symbol

• BTBD14A
• NAC2
• RBB
• RBB
• BEND9
• NAC-2
• BTBD14
• BTBD31
• BTBD14A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.99
kinase perturbation	0.95
biological process	0.91
transcription factor perturbation	0.8
microRNA	0.78

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.11   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 110   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.11   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 110   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0