Tbio SLCO4A1 Solute carrier organic anion transporter family member 4A1

Protein Summary

Description

Mediates the Na(+)-independent transport of organic anions such as the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and of estrone-3-sulfate and taurocholate.

Uniprot Accession IDs

• Q96BD0
• Q9H4T7
• Q9H4T8
• Q9H8P2
• Q9NWX8
• Q9UI35
• Q9UIG7
• OATP4A1

Gene Name

• SLCO4A1

Ensembl ID

• ENST00000217159
• ENSP00000217159
• ENSG00000101187
• ENST00000370507
• ENSP00000359538

Symbol

• OATP1
• OATP4A1
• OATPE
• SLC21A12
• POAT
• OATP1
• OATPE
• OATP-E
• OATP4A1
• OATPRP1
• SLC21A12

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.97
transcription factor perturbation	0.91
PubMedID	0.8
kinase perturbation	0.76
tissue	0.7

Protein Classes

PANTHER Classes

Protein / Transporter / Solute Carrier Organic Anion Transporter Family Member 4a1

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slco Family Of Organic Anion Transporting Polypeptides / Solute Carrier Organic Anion Transporter Family Member 4a1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.97   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 31   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.97   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 31   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0