Tbio FKBP10 Peptidyl-prolyl cis-trans isomerase FKBP10

Protein Summary

Description

PPIases accelerate the folding of proteins during protein synthesis. The protein encoded by this gene belongs to the FKBP-type peptidyl-prolyl cis/trans isomerase (PPIase) family. This protein localizes to the endoplasmic reticulum and acts as a molecular chaperone. Alternatively spliced variants encoding different isoforms have been reported, but their biological validity has not been determined.[provided by RefSeq, Nov 2009]

Uniprot Accession IDs

• Q96AY3
• Q7Z3R4
• Q9H3N3
• Q9H6J3
• Q9H6N5
• Q9UF89
• PPIase FKBP10

Gene Name

• FKBP10

Ensembl ID

• ENST00000321562
• ENSP00000317232
• ENSG00000141756

Symbol

• FKBP65
• OI6
• OI11
• BRKS1
• FKBP65
• PPIASE
• hFKBP65

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.81
protein domain	0.73
histone modification site profile	0.72
transcription factor binding site profile	0.71
tissue	0.66

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 87.85   (req: < 5)

Gene RIFs: 36   (req: <= 3)

Antibodies: 247   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 87.85   (req: >= 5)

Gene RIFs: 36   (req: > 3)

Antibodies: 247   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0