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  6. Mas-related G-protein coupled receptor member F

Tdark Mas-related G-protein coupled receptor member F

Orphan receptor. May bind to a neuropeptide and may regulate nociceptor function and/or development, including the sensation or modulation of pain (By similarity).

 Comments

Property Summary

NCBI Gene PubMed Count 10
PubMed Score 2.28
PubTator Score 275.07

Knowledge Summary

Patent (4,251)

TINX Plot

  Disease Sources (2)

Disease Target Count P-value
Breast cancer 3099 6.48356854873981E-19
ovarian cancer 8492 2.4803857491406E-16
cystic fibrosis 1670 1.4499037024758E-5
intraductal papillary-mucinous adenoma (IPMA) 2956 3.41463080546441E-5
intraductal papillary-mucinous carcinoma (IPMC) 2988 6.20937982144483E-5
invasive ductal carcinoma 2950 1.24059008459478E-4
breast carcinoma 1614 2.92513937675846E-4
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.00209834605250624
primary pancreatic ductal adenocarcinoma 1271 0.00324979014503727
ductal carcinoma in situ 1745 0.00678898479235855
head and neck cancer 270 0.0288710758292508
Disease Target Count Z-score Confidence
Intestinal schistosomiasis 2 3.93 2.0
Ileitis 6 3.64 1.8

Expression

  Differential Expression (11)

Disease log2 FC p
cystic fibrosis -1.304 0.000
primary pancreatic ductal adenocarcinoma 1.186 0.003
intraductal papillary-mucinous adenoma (... -2.300 0.000
intraductal papillary-mucinous carcinoma... -2.200 0.000
intraductal papillary-mucinous neoplasm ... -2.200 0.002
breast carcinoma -1.400 0.000
Breast cancer -1.400 0.000
ductal carcinoma in situ -1.500 0.007
invasive ductal carcinoma -2.700 0.000
ovarian cancer -3.400 0.000
head and neck cancer -1.300 0.029

Synonym

Accession Q96AM1 B3KV43 Q8NBK8 Mas-related gene F protein
Symbols RTA
MRGF
GPR140
GPR168

Gene

MRGPRF

PANTHER Protein Class (2)

  Ortholog (7)

Species Source
Chimp OMA EggNOG
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Horse OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Opossum OMA EggNOG Inparanoid

  TechDev Info (2)

Bryan Roth functional assay
Steve Finkbeiner Neuron specific phenotypes being screened

 GO Function (1)

 GO Component (4)

 Compartment GO Term (35)

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 HCA RNA Cell Line (42)

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 CSPA Cell Line (3)

 UniProt Keyword (11)

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AA Sequence 

MAGNCSWEAHPGNRNKMCPGLSEAPELYSRGFLTIEQIAMLPPPAVMNYIFLLLCLCGLVGNGLVLWFFG      1 - 70
FSIKRNPFSIYFLHLASADVGYLFSKAVFSILNTGGFLGTFADYIRSVCRVLGLCMFLTGVSLLPAVSAE     71 - 140
RCASVIFPAWYWRRRPKRLSAVVCALLWVLSLLVTCLHNYFCVFLGRGAPGAACRHMDIFLGILLFLLCC    141 - 210
PLMVLPCLALILHVECRARRRQRSAKLNHVILAMVSVFLVSSIYLGIDWFLFWVFQIPAPFPEYVTDLCI    211 - 280
CINSSAKPIVYFLAGRDKSQRLWEPLRVVFQRALRDGAELGEAGGSTPNTVTMEMQCPPGNAS           281 - 343
//

Text Mined References (10)

PMID Year Title
24583173 2014 Comparative genomic analysis of eutherian Mas-related G protein-coupled receptor genes.
23376485 2013 Proteomic analysis of podocyte exosome-enriched fraction from normal human urine.
16303743 2005 Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15342556 2004 Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
11551509 2001 A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons.
11181995 2001 The sequence of the human genome.
2109324 1990 RTA, a candidate G protein-coupled receptor: cloning, sequencing, and tissue distribution.