Tdark | Mas-related G-protein coupled receptor member F |
Orphan receptor. May bind to a neuropeptide and may regulate nociceptor function and/or development, including the sensation or modulation of pain (By similarity).
Comments
Disease | Target Count | P-value |
---|---|---|
Breast cancer | 3099 | 6.48356854873981E-19 |
ovarian cancer | 8492 | 2.4803857491406E-16 |
cystic fibrosis | 1670 | 1.4499037024758E-5 |
intraductal papillary-mucinous adenoma (IPMA) | 2956 | 3.41463080546441E-5 |
intraductal papillary-mucinous carcinoma (IPMC) | 2988 | 6.20937982144483E-5 |
invasive ductal carcinoma | 2950 | 1.24059008459478E-4 |
breast carcinoma | 1614 | 2.92513937675846E-4 |
intraductal papillary-mucinous neoplasm (IPMN) | 3289 | 0.00209834605250624 |
primary pancreatic ductal adenocarcinoma | 1271 | 0.00324979014503727 |
ductal carcinoma in situ | 1745 | 0.00678898479235855 |
head and neck cancer | 270 | 0.0288710758292508 |
Disease | log2 FC | p |
---|---|---|
cystic fibrosis | -1.304 | 0.000 |
primary pancreatic ductal adenocarcinoma | 1.186 | 0.003 |
intraductal papillary-mucinous adenoma (... | -2.300 | 0.000 |
intraductal papillary-mucinous carcinoma... | -2.200 | 0.000 |
intraductal papillary-mucinous neoplasm ... | -2.200 | 0.002 |
breast carcinoma | -1.400 | 0.000 |
Breast cancer | -1.400 | 0.000 |
ductal carcinoma in situ | -1.500 | 0.007 |
invasive ductal carcinoma | -2.700 | 0.000 |
ovarian cancer | -3.400 | 0.000 |
head and neck cancer | -1.300 | 0.029 |
Accession | Q96AM1 B3KV43 Q8NBK8 Mas-related gene F protein |
Symbols |
RTA MRGF GPR140 GPR168 |
Species | Source |
---|---|
Chimp | OMA EggNOG |
Mouse | OMA EggNOG Inparanoid |
Rat | OMA EggNOG Inparanoid |
Dog | OMA EggNOG Inparanoid |
Horse | OMA EggNOG Inparanoid |
Cow | OMA EggNOG Inparanoid |
Opossum | OMA EggNOG Inparanoid |
Bryan Roth | functional assay |
Steve Finkbeiner | Neuron specific phenotypes being screened |
MAGNCSWEAHPGNRNKMCPGLSEAPELYSRGFLTIEQIAMLPPPAVMNYIFLLLCLCGLVGNGLVLWFFG 1 - 70 FSIKRNPFSIYFLHLASADVGYLFSKAVFSILNTGGFLGTFADYIRSVCRVLGLCMFLTGVSLLPAVSAE 71 - 140 RCASVIFPAWYWRRRPKRLSAVVCALLWVLSLLVTCLHNYFCVFLGRGAPGAACRHMDIFLGILLFLLCC 141 - 210 PLMVLPCLALILHVECRARRRQRSAKLNHVILAMVSVFLVSSIYLGIDWFLFWVFQIPAPFPEYVTDLCI 211 - 280 CINSSAKPIVYFLAGRDKSQRLWEPLRVVFQRALRDGAELGEAGGSTPNTVTMEMQCPPGNAS 281 - 343 //
PMID | Year | Title |
---|---|---|
24583173 | 2014 | Comparative genomic analysis of eutherian Mas-related G protein-coupled receptor genes. |
23376485 | 2013 | Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. |
16303743 | 2005 | Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. |
15489334 | 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
15342556 | 2004 | Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. |
14702039 | 2004 | Complete sequencing and characterization of 21,243 full-length human cDNAs. |
12477932 | 2002 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |
11551509 | 2001 | A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. |
11181995 | 2001 | The sequence of the human genome. |
2109324 | 1990 | RTA, a candidate G protein-coupled receptor: cloning, sequencing, and tissue distribution. |