Tbio RAB7B Ras-related protein Rab-7b

Protein Summary

Description

Controls vesicular trafficking from endosomes to the trans-Golgi network (TGN). Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL6, and IFNB production in macrophages by promoting TLR9 lysosomal degradation. Also negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Promotes megakaryocytic differentiation by increasing NF-kappa-B-dependent IL6 production and subsequently enhancing the association of STAT3 with GATA1. Not involved in the regulation of the EGF- and EGFR degradation pathway.

Uniprot Accession IDs

• Q96AH8

Gene Name

• RAB7B

Ensembl ID

• ENST00000617070
• ENSP00000482499
• ENSG00000276600
• ENST00000617991
• ENSP00000479762
• ENST00000623597
• ENSP00000485468

Symbol

• RAB7

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.79
molecular function	0.73
cell type or tissue	0.67
tissue	0.66
biological process	0.65

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 518.35   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 128   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 518.35   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 128   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0