Tbio ADIPOR1 Adiponectin receptor protein 1

Protein Summary

Description

Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:25855295, PubMed:12802337). Required for normal glucose and fat homeostasis and for maintaining a normal body weight. ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis. Has high affinity for globular adiponectin and low affinity for full-length adiponectin (By similarity). This gene encodes a protein which acts as a receptor for adiponectin, a hormone secreted by adipocytes which regulates fatty acid catabolism and glucose levels. Binding of adiponectin to the encoded protein results in activation of an AMP-activated kinase signaling pathway which affects levels of fatty acid oxidation and insulin sensitivity. A pseudogene of this gene is located on chromosome 14. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2014]

Uniprot Accession IDs

• Q96A54
• B3KMB0
• Q53HS7
• Q53YY6
• Q9Y360

Gene Name

• ADIPOR1

Ensembl ID

• ENST00000340990
• ENSP00000341785
• ENSG00000159346

Symbol

• PAQR1
• TESBP1A
• CGI45
• PAQR1
• ACDCR1
• CGI-45
• TESBP1A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	0.93
kinase perturbation	0.91
transcription factor binding site profile	0.76
disease perturbation	0.74
disease	0.68

Protein Classes

PANTHER Classes

Protein / Receptor / Adiponectin Receptor Protein 1

DTO Classes

Protein / Receptor / Adiponectin Receptor Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 389.81   (req: < 5)

Gene RIFs: 195   (req: <= 3)

Antibodies: 370   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 389.81   (req: >= 5)

Gene RIFs: 195   (req: > 3)

Antibodies: 370   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0