| Tdark | Protein MAL2 |
Member of the machinery of polarized transport. Required for the indirect transcytotic route at the step of the egress of the transcytosing cargo from perinuclear endosomes in order for it to travel to the apical surface via a raft-dependent pathway.
This gene encodes a multispan transmembrane protein belonging to the MAL proteolipid family. The protein is a component of lipid rafts and, in polarized cells, it primarily localizes to endosomal structures beneath the apical membrane. It is required for transcytosis, an intracellular transport pathway used to deliver membrane-bound proteins and exogenous cargos from the basolateral to the apical surface. [provided by RefSeq, Jul 2008]
This gene encodes a multispan transmembrane protein belonging to the MAL proteolipid family. The protein is a component of lipid rafts and, in polarized cells, it primarily localizes to endosomal structures beneath the apical membrane. It is required for transcytosis, an intracellular transport pathway used to deliver membrane-bound proteins and exogenous cargos from the basolateral to the apical surface. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| Astrocytoma, Pilocytic | 3081 | 6.2e-10 |
| glioblastoma | 5792 | 2.7e-09 |
| pancreatic cancer | 2398 | 5.2e-07 |
| medulloblastoma, large-cell | 6241 | 3.0e-06 |
| ependymoma | 4679 | 1.1e-05 |
| adult high grade glioma | 3801 | 4.1e-05 |
| primitive neuroectodermal tumor | 3035 | 1.1e-04 |
| atypical teratoid / rhabdoid tumor | 5112 | 1.1e-04 |
| Breast cancer | 3578 | 2.8e-04 |
| ovarian cancer | 8520 | 3.1e-04 |
| astrocytic glioma | 2597 | 1.2e-03 |
| subependymal giant cell astrocytoma | 2287 | 1.3e-03 |
| interstitial cystitis | 2312 | 2.2e-03 |
| invasive ductal carcinoma | 2951 | 2.7e-03 |
| medulloblastoma | 720 | 3.6e-03 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 5.3e-03 |
| breast carcinoma | 1638 | 7.3e-03 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 8.3e-03 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 1.3e-02 |
| oligodendroglioma | 2850 | 1.4e-02 |
| Pick disease | 1894 | 2.0e-02 |
| non diabetic and post-ischemic heart failure | 200 | 2.8e-02 |
| ductal carcinoma in situ | 1745 | 3.2e-02 |
| spina bifida | 1074 | 3.9e-02 |
| Disease | log2 FC | p |
|---|---|---|
| adult high grade glioma | -5.000 | 4.1e-05 |
| astrocytic glioma | -4.300 | 1.2e-03 |
| Astrocytoma, Pilocytic | -5.700 | 6.2e-10 |
| atypical teratoid / rhabdoid tumor | -4.500 | 1.1e-04 |
| Breast cancer | 1.200 | 2.8e-04 |
| breast carcinoma | 1.300 | 7.3e-03 |
| ductal carcinoma in situ | 1.600 | 3.2e-02 |
| ependymoma | -3.100 | 1.1e-05 |
| glioblastoma | -4.700 | 2.7e-09 |
| interstitial cystitis | -3.400 | 2.2e-03 |
| intraductal papillary-mucinous adenoma (... | 2.100 | 5.3e-03 |
| intraductal papillary-mucinous carcinoma... | 2.100 | 8.3e-03 |
| intraductal papillary-mucinous neoplasm ... | 2.700 | 1.3e-02 |
| invasive ductal carcinoma | 2.100 | 2.7e-03 |
| medulloblastoma | -2.700 | 3.6e-03 |
| medulloblastoma, large-cell | -5.500 | 3.0e-06 |
| non diabetic and post-ischemic heart fai... | -1.300 | 2.8e-02 |
| oligodendroglioma | -3.200 | 1.4e-02 |
| ovarian cancer | 3.800 | 3.1e-04 |
| pancreatic cancer | 1.900 | 5.2e-07 |
| Pick disease | -2.200 | 2.0e-02 |
| primitive neuroectodermal tumor | -3.800 | 1.1e-04 |
| spina bifida | -2.412 | 3.9e-02 |
| subependymal giant cell astrocytoma | -4.776 | 1.3e-03 |
