Property Summary

NCBI Gene PubMed Count 25
PubMed Score 0.00
PubTator Score 27.59

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (1)

Disease Target Count P-value
breast carcinoma 1614 8.27057170213875E-21
oligodendroglioma 2849 2.29457957956171E-18
pilocytic astrocytoma 3086 8.21391451405806E-10
glioblastoma 5572 1.8023462801541E-7
pancreatic cancer 2300 5.17736428113788E-7
medulloblastoma, large-cell 6234 2.98491008281034E-6
sonic hedgehog group medulloblastoma 1482 9.19047727032347E-6
ependymoma 2514 1.1157571370206E-5
adult high grade glioma 2148 4.05904306485607E-5
primitive neuroectodermal tumor 3031 1.12284025386652E-4
atypical teratoid / rhabdoid tumor 4369 1.13214682386931E-4
Breast cancer 3099 2.75088468998618E-4
ovarian cancer 8492 3.11351180372494E-4
astrocytic glioma 2241 0.00119252358980339
subependymal giant cell astrocytoma 2287 0.00125120063276193
interstitial cystitis 2299 0.00218141356208734
invasive ductal carcinoma 2950 0.00273213576207698
intraductal papillary-mucinous adenoma (IPMA) 2956 0.00529310938443905
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.00833598697346687
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.0127376443910656
Pick disease 1893 0.0203186746508891
non diabetic and post-ischemic heart failure 200 0.0276975455903963
ductal carcinoma in situ 1745 0.0315470279860869
spina bifida 1064 0.0390702555863645

Expression

Synonym

Accession Q969L2 B2R520 Q6ZMD9
Symbols

Gene

PANTHER Protein Class (1)

  Ortholog (6)

Species Source
Mouse OMA Inparanoid
Rat OMA Inparanoid
Dog OMA Inparanoid
Cow OMA Inparanoid
Pig OMA Inparanoid
Xenopus OMA Inparanoid

Gene RIF (9)

PMID Text
25084525 MAL2 and STK16 function to sort secretory soluble cargo into the constitutive secretory pathway in hepatocytes.
21573057 Results prove for the first time the interaction of PLP and MAL2 in oligodendrocytic cells, supporting the transcytotic model of PLP transport previously suggested.
20846453 MAL2 overexpression was highest in serous carcinomas relative to other histological subtypes of ovarian cancer.
19683524 after differentiation, murine oligodendrocyte precursor and human oligodendroglioma derived cell lines up-regulate the expression of MAL2 and accumulate it in an intracellular compartment, exhibiting a peri-centrosomal localization.
19175940 a role for MAL2 in regulating tumor-associated protein mucin expression and/or localisation
17145811 The MAL2 gene was shown to effectively separate these two tumor(chromophobe renal cell carcinoma (RCC) and benign oncocytoma) groups by quantitative reverse transcription-PCR using fresh tissue samples, with similar trends seen on formalin-fixed tissues.
16620967 The results indicate that MAL2 protein genes are not ubiquitously expressed in leukemic bone marrow in children, and that RNA sample parameters may influence measures of gene expression more than commonly appreciated.
14576188 MAL2 protein mRNA species were detected in the thyroid and immunohistochemical analysis of thyroid follicles indicated that MAL2 distributed to the apical membrane
12370246 Data show that MAL2 is essential for transcytosis in HepG2 cells.

AA Sequence

MSAGGASVPPPPNPAVSFPPPRVTLPAGPDILRTYSGAFVCLEILFGGLVWILVASSNVPLPLLQGWVMF      1 - 70
VSVTAFFFSLLFLGMFLSGMVAQIDANWNFLDFAYHFTVFVFYFGAFLLEAAATSLHDLHCNTTITGQPL     71 - 140
LSDNQYNINVAASIFAFMTTACYGCSLGLALRRWRP                                      141 - 176
//

Text Mined References (26)

PMID Year Title
25416956 2014 A proteome-scale map of the human interactome network.
25189868 2015 Gene-smoking interactions identify several novel blood pressure loci in the Framingham Heart Study.
25084525 2014 Serine/threonine kinase 16 and MAL2 regulate constitutive secretion of soluble cargo in hepatic cells.
25080503 2014 Meta-analysis of genome-wide association studies identifies two loci associated with circulating osteoprotegerin levels.
23376485 2013 Proteomic analysis of podocyte exosome-enriched fraction from normal human urine.
23264465 2013 MYADM controls endothelial barrier function through ERM-dependent regulation of ICAM-1 expression.
21573057 2011 Interaction of PLP with GFP-MAL2 in the human oligodendroglial cell line HOG.
20846453 2010 MAL2 and tumor protein D52 (TPD52) are frequently overexpressed in ovarian carcinoma, but differentially associated with histological subtype and patient outcome.
19683524 2009 Characterization of the MAL2-positive compartment in oligodendrocytes.
19668339 2009 Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease.
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