Tbio EXTL1 Exostosin-like 1

Protein Summary

Description

Probable glycosyltransferase. This gene is a member of the multiple exostoses (EXT) family of glycosyltransferases, which function in the chain polymerization of heparan sulfate and heparin. The encoded protein harbors alpha 1,4- N-acetylglucosaminyltransferase activity, and is involved in chain elongation of heparan sulfate and possibly heparin. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q92935
• Q6GSC1

Gene Name

• EXTL1

Ensembl ID

• ENST00000374280
• ENSP00000363398
• ENSG00000158008

Symbol

• EXTL
• EXTL

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.61
PubMedID	0.6
protein domain	0.58
cellular component	0.53
cell line	0.5

Protein Classes

PANTHER Classes

Protein / Transferase / Glycosyltransferase / Exostosin-like 1

DTO Classes

Protein / Enzyme / Transferase / Glycosyltransferase / Exostosin-like 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.55   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 113   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.55   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 113   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0