Property Summary

NCBI Gene PubMed Count 21
PubMed Score 5.83
PubTator Score 2.41

Knowledge Summary


No data available


  Disease Sources (2)

Disease Target Count
IGA Glomerulonephritis 454
Disease Target Count P-value
non-small cell lung cancer 2798 6.06832840859858E-19
lung adenocarcinoma 2714 2.22305437843781E-15
juvenile dermatomyositis 1189 2.38879445032805E-12
ovarian cancer 8492 4.95282501906677E-9
malignant mesothelioma 3163 1.79124206520948E-7
glioblastoma 5572 1.97087725262874E-7
Duchenne muscular dystrophy 602 2.15506674824711E-7
atypical teratoid / rhabdoid tumor 4369 5.31606281584789E-7
acute quadriplegic myopathy 1157 2.42779309396868E-6
pediatric high grade glioma 2712 1.1259326958347E-5
lung cancer 4473 1.25956342633983E-5
ulcerative colitis 2087 1.67824812759549E-5
tuberculosis and treatment for 3 months 327 4.3811237061726E-5
osteosarcoma 7933 2.28687963774662E-4
autosomal dominant Emery-Dreifuss muscular dystrophy 499 4.99051397168356E-4
cutaneous lupus erythematosus 1056 6.34877183187938E-4
primary Sjogren syndrome 789 6.56404864827251E-4
pilocytic astrocytoma 3086 7.08400753636424E-4
primitive neuroectodermal tumor 3031 8.61984540954733E-4
ependymoma 2514 0.00127612176508429
primary pancreatic ductal adenocarcinoma 1271 0.0013075028052396
Pick disease 1893 0.00141269372395011
pancreatic cancer 2300 0.00165806168174988
medulloblastoma, large-cell 6234 0.00195410950928491
group 4 medulloblastoma 1875 0.00232372136640719
gastric carcinoma 832 0.015233227489227
active Crohn's disease 918 0.0166345330462517
aldosterone-producing adenoma 664 0.0221724160316961
acute myeloid leukemia 785 0.0419373803198045



Accession Q92930 Q5JPC4 Q9P293


  Ortholog (9)

Species Source
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA Inparanoid
Cow OMA Inparanoid
Platypus OMA EggNOG
Chicken OMA Inparanoid
Xenopus OMA EggNOG Inparanoid
S.cerevisiae OMA EggNOG

 GWAS Trait (1)

Gene RIF (2)

26471730 Rab8A GTPase Ser(111) phosphorylation is not directly regulated by PINK1 in vitro and demonstrate in cells the time course of Ser(111) phosphorylation of Rab8A, 8B and 13 is markedly delayed compared to phosphorylation of Parkin at Ser(65).
20877624 Observational study of gene-disease association. (HuGE Navigator)

AA Sequence


Text Mined References (25)

PMID Year Title
26471730 2015 Phosphoproteomic screening identifies Rab GTPases as novel downstream targets of PINK1.
24564958 2014 Variability in the common genetic architecture of social-communication spectrum phenotypes during childhood and adolescence.
21269460 2011 Initial characterization of the human central proteome.
21255211 2011 Rab GTPases regulating phagosome maturation are differentially recruited to mycobacterial phagosomes.
20937701 2010 Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors.
20877624 2010 Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
20458337 MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
19717423 2009 The GTPase Rab3b/3c-positive recycling vesicles are involved in cross-presentation in dendritic cells.
19690332 2009 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
19056867 2009 Large-scale proteomics and phosphoproteomics of urinary exosomes.