Tchem MAP4K1 Mitogen-activated protein kinase kinase kinase kinase 1

Protein Summary

Description

Serine/threonine-protein kinase, which may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in hematopoietic lineage decisions and growth regulation. Able to autophosphorylate.

Uniprot Accession IDs

• Q92918

Gene Name

• MAP4K1

Ensembl ID

• ENST00000396857
• ENSP00000380066
• ENSG00000104814
• ENST00000591517
• ENSP00000465039
• ENST00000634395
• ENSP00000489001
• ENSG00000282928
• ENST00000634494
• ENSP00000489158

Symbol

• HPK1
• HPK1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	0.98
molecular function	0.96
drug perturbation	0.87
gene perturbation	0.87
kinase	0.85

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Ste Group / Ste20 Family / Khs Subfamily / Mitogen-activated Protein Kinase Kinase Kinase Kinase 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.89   (req: < 5)

Gene RIFs: 28   (req: <= 3)

Antibodies: 531   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.89   (req: >= 5)

Gene RIFs: 28   (req: > 3)

Antibodies: 531   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 74

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2