Property Summary

NCBI Gene PubMed Count 28
PubMed Score 39.05
PubTator Score 27.18

Knowledge Summary


No data available


  Disease Sources (6)

Disease Target Count P-value
lung carcinoma 2844 9.70238242892098E-20
lung adenocarcinoma 2714 1.97862952165693E-17
non-small cell lung carcinoma 413 1.09318155185341E-16
posterior fossa group A ependymoma 1511 2.87486990166756E-16
atypical teratoid / rhabdoid tumor 4369 6.29139505445451E-11
osteosarcoma 7933 2.3706759368592E-7
Breast cancer 3099 1.88348780074108E-6
ovarian cancer 8492 8.14056733470672E-6
glioblastoma 5572 6.95025384643841E-5
group 3 medulloblastoma 2254 2.12135474755456E-4
medulloblastoma, large-cell 6234 2.66593684128383E-4
subependymal giant cell astrocytoma 2287 3.79033441991424E-4
pituitary cancer 1972 6.08501810193587E-4
adult high grade glioma 2148 7.96610906701544E-4
invasive ductal carcinoma 2950 8.83106689036396E-4
astrocytic glioma 2241 0.00310345956594273
chronic rhinosinusitis 512 0.00330098500280259
oligodendroglioma 2849 0.0114109533361956
cystic fibrosis and chronic rhinosinusitis 213 0.0236615646019363
primitive neuroectodermal tumor 3031 0.0305312953677697
Disease Target Count Z-score Confidence
Osteoporosis 259 0.0 1.0
Disease Target Count Z-score Confidence
Neurodegenerative disease 383 0.0 4.0
Disease Target Count
Spinocerebellar ataxia 27 1


  Differential Expression (20)


Accession Q92915 Q86YN7 Q96QX6 FGF-14
Symbols FHF4


PANTHER Protein Class (2)

  Ortholog (11)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Horse OMA EggNOG
Opossum OMA EggNOG Inparanoid
Anole lizard OMA Inparanoid
Xenopus OMA Inparanoid
Zebrafish OMA Inparanoid

Gene RIF (14)

25659151 identified the PI3K/Akt pathway, the cell-cycle regulator Wee1 kinase, and protein kinase C (PKC) as prospective regulatory nodes of neuronal excitability through modulation of the FGF14:Nav1.6 complex.
25566820 study reports on a two-generation French Canadian family affected with autosomal dominant episodic ataxia caused by a frameshift mutation leading to a premature stop codon in FGF14
24252256 family demonstrates phenotypic variability of FGF14 deletions (SCA 27), fever sensitivity of ataxia and the added value of SNP-array analysis in making a diagnosis
23640885 inhibition of GSK3 reduces the assembly of the FGF14.Nav channel complex, modifies FGF14-dependent regulation of Na(+) currents, and induces dissociation and subcellular redistribution of the native FGF14.Nav channel complex in hippocampal neurons.
22579694 THe present study demonstrates that Spinocerebellar ataxia type 27 (SCA27) caused by FGF14 mutation is rare in Chinese SCA patients.
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
17221845 FGF14 mutations in Ataxia and childhood onset postural tremor.
16211615 a distinct SCA (spinocerebellar ataxia)phenotype (SCA27) is associated with a F145S mutation in the fibroblast growth factor 14 (FGF14) gene on chromosome 13q34.
16166153 these findings implicate FGF14 as a unique modulator of Nav channel activity in the CNS.
15470364 Observational study of gene-disease association. (HuGE Navigator)

AA Sequence

LHDVGETVPKPGVTPSKSTSASAIMNGGKPVNKSKTT                                     211 - 247

Text Mined References (29)

PMID Year Title
26900580 2016 Pathogenic mechanism of recurrent mutations of SCN8A in epileptic encephalopathy.
25659151 2015 Identifying a kinase network regulating FGF14:Nav1.6 complex assembly using split-luciferase complementation.
25566820 2015 A novel frameshift mutation in FGF14 causes an autosomal dominant episodic ataxia.
24252256 2014 A new variable phenotype in spinocerebellar ataxia 27 (SCA 27) caused by a deletion in the FGF14 gene.
23640885 2013 The fibroblast growth factor 14·voltage-gated sodium channel complex is a new target of glycogen synthase kinase 3 (GSK3).
23551011 2013 Genome-wide association study of pre-eclampsia detects novel maternal single nucleotide polymorphisms and copy-number variants in subsets of the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study cohort.
23509962 2013 A genome-wide search for common SNP x SNP interactions on the risk of venous thrombosis.
23166209 2012 Impact of ancestry and common genetic variants on QT interval in African Americans.
22579694 2012 Spinocerebellar ataxia type 27 (SCA27) is an uncommon cause of dominant ataxia among Chinese Han population.
22020285 2011 Image-based genome-wide siRNA screen identifies selective autophagy factors.