Tchem ABCC2 Canalicular multispecific organic anion transporter 1

Protein Summary

Description

Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter. The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q92887
• B2RMT8
• Q14022
• Q5T2B1
• Q92500
• Q92798
• Q99663
• Q9UMS2

Gene Name

• ABCC2

Ensembl ID

• ENST00000370449
• ENSP00000359478
• ENSG00000023839
• ENST00000647814
• ENSP00000497274

Symbol

• CMOAT
• CMOAT1
• CMRP
• MRP2
• DJS
• MRP2
• cMRP
• ABC30
• CMOAT

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
chemical	1
drug	1
molecular function	1
biological term	0.97
protein domain	0.92

Protein Classes

PANTHER Classes

Protein / Transporter / Atp-binding Cassette (Abc) Transporter / Canalicular Multispecific Organic Anion Transporter 1

DTO Classes

Protein / Transporter / Atp-binding Cassette Transporter Family / Abcc Subfamily / Canalicular Multispecific Organic Anion Transporter 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1079.46   (req: < 5)

Gene RIFs: 261   (req: <= 3)

Antibodies: 322   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1079.46   (req: >= 5)

Gene RIFs: 261   (req: > 3)

Antibodies: 322   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0