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Tbio Neurogenin-1

Acts as a transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis (By similarity).

 Comments

Property Summary

NCBI Gene PubMed Count 21
PubMed Score 132.51
PubTator Score 63.57

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (3)

Disease Target Count P-value
group 3 medulloblastoma 4104 6.8e-08
medulloblastoma, large-cell 6241 1.8e-03
Disease Target Count Z-score Confidence
Colorectal cancer 25 4.155 2.1
Cerebellar liponeurocytoma 1 3.059 1.5

Expression

  Differential Expression (2)

Disease log2 FC p
group 3 medulloblastoma 3.300 6.8e-08
medulloblastoma, large-cell 2.600 1.8e-03

Synonym

Accession Q92886 Q5U0Q9 Q96HE1 NGN-1
Symbols AKA
ngn1
Math4C
bHLHa6
NEUROD3

Gene

NEUROG1

PANTHER Protein Class (2)

  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG

 UniProt Keyword (10)

 GO Function (7)

 GO Component (2)

 GO Process (29)

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 Compartment GO Term (11)

 MGI Phenotype (4)

 GWAS Trait (1)

 HCA RNA Cell Line (4)

Pathway (3)

Gene RIF (15)

AA Sequence 

MPARLETCISDLDCASSSGSDLSGFLTDEEDCARLQQAASASGPPAPARRGAPNISRASEVPGAQDDEQE      1 - 70
RRRRRGRTRVRSEALLHSLRRSRRVKANDRERNRMHNLNAALDALRSVLPSFPDDTKLTKIETLRFAYNY     71 - 140
IWALAETLRLADQGLPGGGARERLLPPQCVPCLPGPPSPASDAESWGSGAAAASPLSDPSSPAASEDFTY    141 - 210
RPGDPVFSFPSLPKDLLHTTPCFIPYH                                               211 - 237
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Text Mined References (21)

PMID Year Title