Tbio | Neurogenin-1 |
Acts as a transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis (By similarity).
Comments
Disease | Target Count | P-value |
---|---|---|
group 4 medulloblastoma | 1875 | 1.99557298884718E-10 |
medulloblastoma, large-cell | 6234 | 0.00178129452694893 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Colorectal Cancer | 62 | 4.173 | 2.1 |
Cerebellar liponeurocytoma | 2 | 3.166 | 1.6 |
Disease | log2 FC | p |
---|---|---|
group 4 medulloblastoma | 4.200 | 0.000 |
medulloblastoma, large-cell | 2.600 | 0.002 |
Species | Source |
---|---|
Chimp | OMA EggNOG |
Macaque | OMA EggNOG Inparanoid |
Mouse | OMA EggNOG Inparanoid |
Rat | OMA EggNOG Inparanoid |
Cow | OMA EggNOG Inparanoid |
Anole lizard | OMA EggNOG Inparanoid |
Xenopus | OMA EggNOG Inparanoid |
PMID | Text |
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25403753 | Results show that neurogenin-1 and -2 drive homogeneous differentiation of human stem cells into bipolar neurons in 4 days in defined media. |
23419067 | We propose NEUROG1 as a new gene for syndromic autosomal recessive hearing loss and congenital cranial dysinnervation disorder |
23034738 | Methylation of NEUROG1 is associated with recurrence following adjuvant FOLFOX in Stages II/III colorectal cancer. |
21326223 | NEUROG1 gene is frequently found in patients, diagnosed with colorectal cancer. |
20102160 | The basic helix-loop-helix region of human neurogenin 1 is a monomeric natively unfolded protein which forms a "fuzzy" complex upon DNA binding. |
19813087 | Stable expression of a single gene Ngn1 in F3 cells induces not simply neurogenic but multifunctional changes that potentially affect the differentiation of human NSC via a reorganization of complex gene regulatory networks. |
19086053 | Observational study of gene-disease association. (HuGE Navigator) |
18799289 | Major alleles on two NEUROG1-associated SNPs (rs2344484-C-allele and rs8192558-G-allele) were significantly more prevalent among patients. this is the first study to examine brain morphological and neurocognitive correlates of NEUROG1. |
18799289 | Observational study of gene-disease association. (HuGE Navigator) |
18053270 | Observational study of gene-disease association. (HuGE Navigator) |
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PMID | Year | Title |
---|---|---|
25416956 | 2014 | A proteome-scale map of the human interactome network. |
25403753 | 2014 | Rapid neurogenesis through transcriptional activation in human stem cells. |
23419067 | 2013 | A boy with homozygous microdeletion of NEUROG1 presents with a congenital cranial dysinnervation disorder [Moebius syndrome variant]. |
23034738 | 2013 | Methylation and microsatellite status and recurrence following adjuvant FOLFOX in colorectal cancer. |
21697133 | 2011 | Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method. |
21326223 | 2011 | Methylation of NEUROG1 in serum is a sensitive marker for the detection of early colorectal cancer. |
20102160 | 2010 | The basic helix-loop-helix region of human neurogenin 1 is a monomeric natively unfolded protein which forms a "fuzzy" complex upon DNA binding. |
19813087 | 2010 | Stable expression of neurogenin 1 induces LGR5, a novel stem cell marker, in an immortalized human neural stem cell line HB1.F3. |
19086053 | 2009 | Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. |
18799289 | 2008 | Basic helix-loop-helix transcription factor NEUROG1 and schizophrenia: effects on illness susceptibility, MRI brain morphometry and cognitive abilities. |
More... |