Tbio DNASE1L2 Deoxyribonuclease-1-like 2

Protein Summary

Description

Divalent cation-dependent acid DNA endonuclease involved in the breakdown of the nucleus during corneocyte formation of epidermal keratinocytes. May play an immune role by eliminating harmful DNA released into the extracellular environment by damaged epidermal cells.

Uniprot Accession IDs

• Q92874
• E9PBY4
• Q6JVM2
• Q6JVM3

Gene Name

• DNASE1L2

Ensembl ID

• ENST00000320700
• ENSP00000316938
• ENSG00000167968
• ENST00000382437
• ENSP00000371874
• ENST00000564065
• ENSP00000454562
• ENST00000567494
• ENSP00000455358
• ENST00000613572
• ENSP00000482627

Symbol

• DHP1
• DNAS1L2
• DNAS1L2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.67
cell type or tissue	0.66
phenotype	0.59
tissue sample	0.59
transcription factor	0.59

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.23   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 44   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.23   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 44   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0