Property Summary

NCBI Gene PubMed Count 78
PubMed Score 95.44
PubTator Score 107.83

Knowledge Summary


No data available


  Disease Sources (3)

Disease Target Count
Chronic lymphoid leukemia, disease 10
Disease Target Count P-value
psoriasis 6685 2.5566697345421E-20
posterior fossa group A ependymoma 1511 6.64691050232242E-15
atypical teratoid / rhabdoid tumor 4369 2.50098620647452E-12
group 4 medulloblastoma 1875 2.67994507950141E-10
adult high grade glioma 2148 2.75522253491729E-8
pilocytic astrocytoma 3086 3.76319869887002E-8
lung adenocarcinoma 2714 5.43457207943655E-8
medulloblastoma, large-cell 6234 6.64962830229381E-8
glioblastoma 5572 7.12734974243186E-8
facioscapulohumeral dystrophy 286 1.01547060335253E-5
osteosarcoma 7933 4.60718978030084E-5
primitive neuroectodermal tumor 3031 7.49822499286699E-5
ovarian cancer 8492 3.80622667630369E-4
colon cancer 1475 0.00104262807486647
invasive ductal carcinoma 2950 0.00542631004732113
astrocytic glioma 2241 0.0145477051235176
oligodendroglioma 2849 0.0499599918994283
Disease Target Count Z-score Confidence
Cancer 2346 4.267 2.1


  Differential Expression (17)

Disease log2 FC p
astrocytic glioma -1.700 0.015
posterior fossa group A ependymoma -2.000 0.000
oligodendroglioma -1.200 0.050
glioblastoma -2.100 0.000
osteosarcoma 1.177 0.000
group 4 medulloblastoma -2.600 0.000
atypical teratoid / rhabdoid tumor -2.700 0.000
medulloblastoma, large-cell -2.800 0.000
primitive neuroectodermal tumor -2.300 0.000
colon cancer -1.200 0.001
adult high grade glioma -2.500 0.000
pilocytic astrocytoma -1.300 0.000
lung adenocarcinoma -1.200 0.000
invasive ductal carcinoma -1.300 0.005
ovarian cancer 1.200 0.000
psoriasis 1.300 0.000
facioscapulohumeral dystrophy 2.100 0.000


Accession Q92843 A8K0F4 Q2M3U0 Q5U0H4 Bcl2-L-2
Symbols BCLW


PANTHER Protein Class (1)


1ZY3   1MK3   1O0L   2Y6W   4CIM  

  Ortholog (7)

MLP Assay (3)

AID Type Active / Inconclusive / Inactive Description
952 screening 47 / 447 / 194372 Multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-W.
1330 confirmatory 18 / 0 / 816 Multiplexed dose response screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-W.
2081 confirmatory 5 / 0 / 37 Confirmation dose response of hits from multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-W

Gene RIF (40)

27048913 Genetic and pharmacological inhibition of BCL-W and BCL-XL causes directed elimination of senescent cells.
26155940 Data show that BCL2-like 2 protein (BCL2L2) is a direct target of micrRNA miR-29b.
25874488 miR-15a acts as a tumor suppressor in NSCLC by directly targeting BCL2L2 and may serve as a potential diagnostic biomarker and therapeutic target for NSCLC.
25846734 these results indicate that miR-335 acts as a novel tumor suppressor to regulate ccRCC cell proliferation and invasion through downregulation of BCL-W expression.
25371206 The crystal structures of BCL-W and BCL-XL, along with cellular, studies reveal critical features of the BH3 domains of pro-survival proteins that distinguish them functionally from their pro-apoptotic counterparts.
24946210 HDMF inhibits Bcl-w-induced neurosphere formation and the expression of glioma stem cell markers, such as Musashi, Sox-2 and c-myc.
24747052 Crystal structure of human BCL-W in complex with different DARPins is virtually identical to the ligand-free conformation of its closest relative BCL-XL.
24646834 A structural basis for a conserved binding mechanism between p53DBD and the anti-apoptotic Bcl-2 family proteins.
24552705 Bcl-w-induced Sp1 activation is a potential marker for aggressiveness of glioblastoma multiforme.
23708561 MiR-335 lacks of expression brings about the abnormal accumulation of Bcl-w.

AA Sequence


Text Mined References (88)

PMID Year Title
27107012 2016 Pooled-matrix protein interaction screens using Barcode Fusion Genetics.
27048913 2016 Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL.
26155940 2015 miR-29b attenuates tumorigenicity and stemness maintenance in human glioblastoma multiforme by directly targeting BCL2L2.
25874488 2015 MicroRNA-15a induces cell apoptosis and inhibits metastasis by targeting BCL2L2 in non-small cell lung cancer.
25846734 2015 miR-335 inhibits the proliferation and invasion of clear cell renal cell carcinoma cells through direct suppression of BCL-W.
25416956 2014 A proteome-scale map of the human interactome network.
25371206 2014 The functional differences between pro-survival and pro-apoptotic B cell lymphoma 2 (Bcl-2) proteins depend on structural differences in their Bcl-2 homology 3 (BH3) domains.
24946210 2014 3-Hydroxy-3',4'-dimethoxyflavone suppresses Bcl-w-induced invasive potentials and stemness in glioblastoma multiforme.
24747052 2014 Co-crystallization with conformation-specific designed ankyrin repeat proteins explains the conformational flexibility of BCL-W.
24646834 2014 A conserved mechanism for binding of p53 DNA-binding domain and anti-apoptotic Bcl-2 family proteins.