Tchem BCL2L2 Bcl-2-like protein 2

Protein Summary

Description

Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX. This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream PABPN1 (poly(A) binding protein, nuclear 1) gene. [provided by RefSeq, Dec 2010]

Uniprot Accession IDs

• Q92843
• A8K0F4
• Q2M3U0
• Q5U0H4
• Bcl2-L-2

Gene Name

• BCL2L2

Ensembl ID

• ENST00000250405
• ENSP00000250405
• ENSG00000129473
• ENST00000553781
• ENSP00000451320
• ENSG00000258643
• ENST00000557008
• ENSP00000452479

Symbol

• BCLW
• KIAA0271
• BCLW
• BCL-W
• PPP1R51
• BCL2-L-2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.92
disease perturbation	0.87
microRNA	0.74
transcription factor perturbation	0.74
cellular component	0.68

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Bcl-2-like Protein 2

DTO Classes

Protein / Signaling / Bcl-2-like Protein 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 168.13   (req: < 5)

Gene RIFs: 56   (req: <= 3)

Antibodies: 390   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 168.13   (req: >= 5)

Gene RIFs: 56   (req: > 3)

Antibodies: 390   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 17

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1