NELL1
Protein kinase C-binding protein NELL1
Protein Summary
Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization. This gene encodes a cytoplasmic protein that contains epidermal growth factor (EGF)-like repeats. The encoded heterotrimeric protein may be involved in cell growth regulation and differentiation. A similar protein in rodents is involved in craniosynostosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
- ENST00000357134
- ENSP00000349654
- ENSG00000165973
- ENST00000532434
- ENSP00000437170
- NRP1
- NRP1
- IDH3GL
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 1 | ||
trait | 1 | ||
phenotype | 0.77 | ||
disease | 0.67 | ||
PubMedID | 0.58 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 123.22 (req: < 5)
Gene RIFs: 52 (req: <= 3)
Antibodies: 124 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 123.22 (req: >= 5)
Gene RIFs: 52 (req: > 3)
Antibodies: 124 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0