| Tbio | Zinc finger protein ubi-d4 |
May be a transcription factor required for the apoptosis response following survival factor withdrawal from myeloid cells. Might also have a role in the development and maturation of lymphoid cells.
The protein encoded by this gene is a member of the d4 domain family, characterized by a zinc finger-like structural motif. This protein functions as a transcription factor which is necessary for the apoptotic response following deprivation of survival factors. It likely serves a regulatory role in rapid hematopoietic cell growth and turnover. This gene is considered a candidate gene for multiple endocrine neoplasia type I, an inherited cancer syndrome involving multiple parathyroid, enteropancreatic, and pituitary tumors. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the d4 domain family, characterized by a zinc finger-like structural motif. This protein functions as a transcription factor which is necessary for the apoptotic response following deprivation of survival factors. It likely serves a regulatory role in rapid hematopoietic cell growth and turnover. This gene is considered a candidate gene for multiple endocrine neoplasia type I, an inherited cancer syndrome involving multiple parathyroid, enteropancreatic, and pituitary tumors. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| Multiple myeloma | 1332 | 5.8e-06 |
| ovarian cancer | 8520 | 1.1e-03 |
| astrocytoma | 1146 | 1.9e-03 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Hemopneumothorax | 4 | 4.461 | 2.2 |
| Coffin-Siris syndrome | 17 | 3.614 | 1.8 |
| Disease | log2 FC | p |
|---|---|---|
| astrocytoma | 1.900 | 1.9e-03 |
| Multiple myeloma | 1.332 | 5.8e-06 |
| ovarian cancer | 1.700 | 1.1e-03 |
MAAVVENVVKLLGEQYYKDAMEQCHNYNARLCAERSVRLPFLDSQTGVAQSNCYIWMEKRHRGPGLASGQ 1 - 70 LYSYPARRWRKKRRAHPPEDPRLSFPSIKPDTDQTLKKEGLISQDGSSLEALLRTDPLEKRGAPDPRVDD 71 - 140 DSLGEFPVTNSRARKRILEPDDFLDDLDDEDYEEDTPKRRGKGKSKGKGVGSARKKLDASILEDRDKPYA 141 - 210 CDICGKRYKNRPGLSYHYAHSHLAEEEGEDKEDSQPPTPVSQRSEEQKSKKGPDGLALPNNYCDFCLGDS 211 - 280 KINKKTGQPEELVSCSDCGRSGHPSCLQFTPVMMAAVKTYRWQCIECKCCNICGTSENDDQLLFCDDCDR 281 - 350 GYHMYCLTPSMSEPPEGSWSCHLCLDLLKEKASIYQNQNSS 351 - 391 //
