Tbio RDH5 11-cis retinol dehydrogenase

Protein Summary

Description

Stereospecific 11-cis retinol dehydrogenase, which catalyzes the final step in the biosynthesis of 11-cis retinaldehyde, the universal chromophore of visual pigments. Also able to oxidize 9-cis-retinol and 13-cis-retinol, but not all-trans-retinol. Active in the presence of NAD as cofactor but not in the presence of NADP. This gene encodes an enzyme belonging to the short-chain dehydrogenases/reductases (SDR) family. This retinol dehydrogenase functions to catalyze the final step in the biosynthesis of 11-cis retinaldehyde, which is the universal chromophore of visual pigments. Mutations in this gene cause autosomal recessive fundus albipunctatus, a rare form of night blindness that is characterized by a delay in the regeneration of cone and rod photopigments. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring upstream BLOC1S1 (biogenesis of lysosomal organelles complex-1, subunit 1) gene. [provided by RefSeq, Dec 2010]

Uniprot Accession IDs

• Q92781
• O00179
• Q8TAI2
• 11-cis RDH

Gene Name

• RDH5

Ensembl ID

• ENST00000257895
• ENSP00000257895
• ENSG00000135437
• ENST00000548082
• ENSP00000447128

Symbol

• HSD17B9
• RDH1
• SDR9C5
• RDH1
• 9cRDH
• SDR9C5
• HSD17B9

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.93
cell type or tissue	0.68
cellular component	0.68
tissue sample	0.57
transcription factor	0.51

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Reductase / 11-cis Retinol Dehydrogenase

Protein / Oxidoreductase / Dehydrogenase / 11-cis Retinol Dehydrogenase

DTO Classes

Protein / Enzyme / Oxidoreductase / Dehydrogenase / 11-cis Retinol Dehydrogenase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 87.26   (req: < 5)

Gene RIFs: 27   (req: <= 3)

Antibodies: 93   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 87.26   (req: >= 5)

Gene RIFs: 27   (req: > 3)

Antibodies: 93   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0