FRZB
Secreted frizzled-related protein 3
Protein Summary
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development. The protein encoded by this gene is a secreted protein that is involved in the regulation of bone development. Defects in this gene are a cause of female-specific osteoarthritis (OA) susceptibility. [provided by RefSeq, Apr 2010]
- ENST00000295113
- ENSP00000295113
- ENSG00000162998
- FIZ
- FRE
- FRP
- FRZB1
- SFRP3
- FRE
- OS1
- FZRB
- hFIZ
- FRITZ
- FRP-3
- FRZB1
- SFRP3
- SRFP3
- FRZB-1
- FRZB-PEN
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
PubMedID | 0.98 | ||
protein domain | 0.85 | ||
gene perturbation | 0.76 | ||
virus perturbation | 0.76 | ||
histone modification site profile | 0.74 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 523.52 (req: < 5)
Gene RIFs: 52 (req: <= 3)
Antibodies: 316 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 523.52 (req: >= 5)
Gene RIFs: 52 (req: > 3)
Antibodies: 316 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 17
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0