Tbio NDRG1 Protein NDRG1

Protein Summary

Description

Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumor suppressor in many cell types. Necessary but not sufficient for p53/TP53-mediated caspase activation and apoptosis. Has a role in cell trafficking, notably of the Schwann cell, and is necessary for the maintenance and development of the peripheral nerve myelin sheath. Required for vesicular recycling of CDH1 and TF. May also function in lipid trafficking. Protects cells from spindle disruption damage. Functions in p53/TP53-dependent mitotic spindle checkpoint. Regulates microtubule dynamics and maintains euploidy. This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein involved in stress responses, hormone responses, cell growth, and differentiation. The encoded protein is necessary for p53-mediated caspase activation and apoptosis. Mutations in this gene are a cause of Charcot-Marie-Tooth disease type 4D, and expression of this gene may be a prognostic indicator for several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]

Uniprot Accession IDs

• Q92597
• B3KR80
• B7Z446
• O15207
• Q6IBG2
• Q9NYR6
• Q9UK29

Gene Name

• NDRG1

Ensembl ID

• ENST00000323851
• ENSP00000319977
• ENSG00000104419
• ENST00000414097
• ENSP00000404854
• ENST00000522476
• ENSP00000427894
• ENST00000537882
• ENSP00000437443

Symbol

• CAP43
• DRG1
• RTP
• GC4
• RTP
• DRG1
• NDR1
• NMSL
• TDD5
• CAP43
• CMT4D
• DRG-1
• HMSNL
• RIT42
• TARG1
• PROXY1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
kinase perturbation	1
protein complex	1
transcription factor perturbation	1
gene perturbation	0.96

Protein Classes

PANTHER Classes

Protein / ... / Serine Protease / Protein Ndrg1

DTO Classes

Protein / Enzyme / Protease / Serine Protease / Protein Ndrg1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 401.45   (req: < 5)

Gene RIFs: 218   (req: <= 3)

Antibodies: 582   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 401.45   (req: >= 5)

Gene RIFs: 218   (req: > 3)

Antibodies: 582   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0