Property Summary

NCBI Gene PubMed Count 25
PubMed Score 55.61
PubTator Score 13.24

Knowledge Summary


No data available


  Disease Sources (4)

Disease Target Count P-value
juvenile dermatomyositis 1189 1.11012641546723E-7
Duchenne muscular dystrophy 602 9.58113371131287E-7
Amyotrophic Lateral Sclerosis 432 4.91808553947943E-5
pituitary cancer 1972 7.77397694903292E-5
medulloblastoma, large-cell 6234 9.48715577348802E-4
osteosarcoma 7933 0.00128571065486398
chronic lymphosyte leukemia 232 0.00273574862878439
autosomal dominant Emery-Dreifuss muscular dystrophy 499 0.00518556810919886
Multiple myeloma 1328 0.00637718141670176
hereditary spastic paraplegia 313 0.00779101906344728
active Crohn's disease 918 0.00846984413567673
ovarian cancer 8492 0.0110711747836057
Pick disease 1893 0.0156181848868356
active ulcerative colitis 477 0.0196854615444925
Waldenstrons macroglobulinemia 765 0.0340315747807143
Disease Target Count Z-score Confidence
Osteoporosis 259 0.0 2.0
Disease Target Count Z-score Confidence
Cancer 2346 0.0 4.0



Accession Q92520 A6NDN2 A8K3R7
Symbols ILEI


  Ortholog (12)

 GO Function (1)

Gene RIF (10)

26498278 FAM3C expression was dramatically increased in esophageal squamous cell carcinoma and might serve as a valuable prognostic indicator for esophageal squamous cell carcinoma patients after surgery
25212966 Altered subcellular ILEI localization strongly correlates with high tumor cell-associated uPAR protein expression.
24738665 Our findings indicate that cytoplasmic ILEI expression is a potential marker of EMT and tumour progression in colorectal cancer. ILEI is an independent predictive factor associated with poor prognosis in colorectal cancer.
24072492 ILEI could induce, as well as maintain, CD24(low)CD44(high) subpopulation in A549 cells treated with TGF-beta, which might explain its capability to induce metastatic progression.
22159821 At the FAM3C gene locus where rs7776725 was located, we identified several other SNPs (rs4727922, rs1803389, rs718766 and rs7793554) that were also associated with BMD.
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
19396169 Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
19109932 Data show that FAM3C is decreased in the CSF of temporal lobe epilepsy patients.
16959614 ILEI is overexpressed and/or altered in intracellular localization in multiple human tumors.
12160727 A cytokine-like protein found in almost all tissues.

AA Sequence

GWPEVVEMEGCIPQKQD                                                         211 - 227

Text Mined References (30)

PMID Year Title
26498278 2015 Prognostic significance of FAM3C in esophageal squamous cell carcinoma.
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
25416956 2014 A proteome-scale map of the human interactome network.
25212966 2014 Interleukin-like epithelial-to-mesenchymal transition inducer activity is controlled by proteolytic processing and plasminogen-urokinase plasminogen activator receptor system-regulated secretion during breast cancer progression.
24945404 2014 Phenotypic dissection of bone mineral density reveals skeletal site specificity and facilitates the identification of novel loci in the genetic regulation of bone mass attainment.
24738665 2014 ILEI: a novel marker for epithelial-mesenchymal transition and poor prognosis in colorectal cancer.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
24072492 2014 ILEI drives epithelial to mesenchymal transition and metastatic progression in the lung cancer cell line A549.
23533145 2013 In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
23376485 2013 Proteomic analysis of podocyte exosome-enriched fraction from normal human urine.