Tbio SEC14L1 SEC14-like protein 1

Protein Summary

Description

May play a role in innate immunity by inhibiting the antiviral RIG-I signaling pathway. In this pathway, functions as a negative regulator of DDX58/RIG-I, the cytoplasmic sensor of viral nucleic acids. Prevents the interaction of DDX58 with MAVS/IPS1, an important step in signal propagation (PubMed:23843640). May also regulate the SLC18A3 and SLC5A7 cholinergic transporters (PubMed:17092608). The protein encoded by this gene belongs to the SEC14 cytosolic factor family. It has similarity to yeast SEC14 and to Japanese flying squid RALBP which suggests a possible role of the gene product in an intracellular transport system. Multiple alternatively spliced transcript variants have been found for this gene; some variants represent read-through transcripts that include exons from the upstream gene C17orf86. [provided by RefSeq, Feb 2011]

Uniprot Accession IDs

• Q92503
• A8K4E8
• B4DDI5
• D5G3K1
• Q99780

Gene Name

• SEC14L1

Ensembl ID

• ENST00000392476
• ENSP00000376268
• ENSG00000129657
• ENST00000430767
• ENSP00000408169
• ENST00000431431
• ENSP00000389838
• ENST00000436233
• ENSP00000390392
• ENST00000443798
• ENSP00000406030
• ENST00000585618
• ENSP00000466581
• ENST00000591437
• ENSP00000467934

Symbol

• SEC14L
• SEC14L
• PRELID4A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.99
transcription factor binding site profile	0.99
transcription factor perturbation	0.96
disease perturbation	0.93
transcription factor	0.89

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.96   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 53   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.96   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 53   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0