| Tbio | SEC14-like protein 1 |
May play a role in innate immunity by inhibiting the antiviral RIG-I signaling pathway. In this pathway, functions as a negative regulator of DDX58/RIG-I, the cytoplasmic sensor of viral nucleic acids. Prevents the interaction of DDX58 with MAVS/IPS1, an important step in signal propagation (PubMed:23843640). May also regulate the SLC18A3 and SLC5A7 cholinergic transporters (PubMed:17092608).
The protein encoded by this gene belongs to the SEC14 cytosolic factor family. It has similarity to yeast SEC14 and to Japanese flying squid RALBP which suggests a possible role of the gene product in an intracellular transport system. Multiple alternatively spliced transcript variants have been found for this gene; some variants represent read-through transcripts that include exons from the upstream gene C17orf86. [provided by RefSeq, Feb 2011]
The protein encoded by this gene belongs to the SEC14 cytosolic factor family. It has similarity to yeast SEC14 and to Japanese flying squid RALBP which suggests a possible role of the gene product in an intracellular transport system. Multiple alternatively spliced transcript variants have been found for this gene; some variants represent read-through transcripts that include exons from the upstream gene C17orf86. [provided by RefSeq, Feb 2011]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| ulcerative colitis | 1819 | 1.7e-08 |
| lung adenocarcinoma | 2716 | 3.3e-06 |
| Pick disease | 1894 | 5.9e-06 |
| medulloblastoma, large-cell | 6241 | 1.6e-05 |
| nephrosclerosis | 333 | 2.4e-05 |
| adrenocortical carcinoma | 1428 | 3.7e-05 |
| ovarian cancer | 8520 | 3.8e-05 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 5.4e-05 |
| malignant mesothelioma | 3232 | 7.7e-05 |
| interstitial cystitis | 2312 | 4.1e-04 |
| psoriasis | 6694 | 4.3e-03 |
| group 4 medulloblastoma | 1855 | 6.2e-03 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 6.4e-03 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 7.9e-03 |
| Rheumatoid arthritis | 1191 | 9.0e-03 |
| astrocytoma | 1146 | 9.3e-03 |
| subependymal giant cell astrocytoma | 2287 | 9.8e-03 |
| adult high grade glioma | 3801 | 1.1e-02 |
| non primary Sjogren syndrome sicca | 891 | 1.8e-02 |
| spina bifida | 1074 | 3.8e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Brachial plexus neuropathy | 6 | 4.797 | 2.4 |
| Nonepidermolytic palmoplantar keratoderma | 12 | 3.954 | 2.0 |
| interleukin-7 receptor alpha deficiency | 18 | 3.021 | 1.5 |
| Disease | log2 FC | p |
|---|---|---|
| adrenocortical carcinoma | -1.267 | 3.7e-05 |
| adult high grade glioma | -1.100 | 1.1e-02 |
| astrocytoma | 1.400 | 9.3e-03 |
| group 4 medulloblastoma | -1.300 | 6.2e-03 |
| interstitial cystitis | 1.700 | 4.1e-04 |
| intraductal papillary-mucinous adenoma (... | -1.300 | 6.4e-03 |
| intraductal papillary-mucinous carcinoma... | -2.300 | 5.4e-05 |
| intraductal papillary-mucinous neoplasm ... | -1.400 | 7.9e-03 |
| lung adenocarcinoma | -1.180 | 3.3e-06 |
| malignant mesothelioma | -1.200 | 7.7e-05 |
| medulloblastoma, large-cell | -1.800 | 1.6e-05 |
| nephrosclerosis | 1.116 | 2.4e-05 |
| non primary Sjogren syndrome sicca | 1.100 | 1.8e-02 |
| ovarian cancer | -1.300 | 3.8e-05 |
| Pick disease | 1.700 | 5.9e-06 |
| psoriasis | -1.300 | 4.3e-03 |
| Rheumatoid arthritis | 1.500 | 9.0e-03 |
| spina bifida | -1.058 | 3.8e-02 |
| subependymal giant cell astrocytoma | -1.749 | 9.8e-03 |
| ulcerative colitis | 2.300 | 1.7e-08 |
MVQKYQSPVRVYKYPFELIMAAYERRFPTCPLIPMFVGSDTVNEFKSEDGAIHVIERRCKLDVDAPRLLK 1 - 70 KIAGVDYVYFVQKNSLNSRERTLHIEAYNETFSNRVIINEHCCYTVHPENEDWTCFEQSASLDIKSFFGF 71 - 140 ESTVEKIAMKQYTSNIKKGKEIIEYYLRQLEEEGITFVPRWSPPSITTSSETSSSSSKKQAASMAVVIPE 141 - 210 AALKEGLSGDALSSPSAPEPVVGTPDDKLDADYIKRYLGDLTPLQESCLIRLRQWLQETHKGKIPKDEHI 211 - 280 LRFLRARDFNIDKAREIMCQSLTWRKQHQVDYILETWTPPQVLQDYYAGGWHHHDKDGRPLYVLRLGQMD 281 - 350 TKGLVRALGEEALLRYVLSINEEGLRRCEENTKVFGRPISSWTCLVDLEGLNMRHLWRPGVKALLRIIEV 351 - 420 VEANYPETLGRLLILRAPRVFPVLWTLVSPFIDDNTRRKFLIYAGNDYQGPGGLLDYIDKEIIPDFLSGE 421 - 490 CMCEVPEGGLVPKSLYRTAEELENEDLKLWTETIYQSASVFKGAPHEILIQIVDASSVITWDFDVCKGDI 491 - 560 VFNIYHSKRSPQPPKKDSLGAHSITSPGGNNVQLIDKVWQLGRDYSMVESPLICKEGESVQGSHVTRWPG 561 - 630 FYILQWKFHSMPACAASSLPRVDDVLASLQVSSHKCKVMYYTEVIGSEDFRGSMTSLESSHSGFSQLSAA 631 - 700 TTSSSQSHSSSMISR 701 - 715 //
