| Tbio | SEC14-like protein 1 |
May play a role in innate immunity by inhibiting the antiviral RIG-I signaling pathway. In this pathway, functions as a negative regulator of DDX58/RIG-I, the cytoplasmic sensor of viral nucleic acids. Prevents the interaction of DDX58 with MAVS/IPS1, an important step in signal propagation (PubMed:23843640). May also regulate the SLC18A3 and SLC5A7 cholinergic transporters (PubMed:17092608).
The protein encoded by this gene belongs to the SEC14 cytosolic factor family. It has similarity to yeast SEC14 and to Japanese flying squid RALBP which suggests a possible role of the gene product in an intracellular transport system. Multiple alternatively spliced transcript variants have been found for this gene; some variants represent read-through transcripts that include exons from the upstream gene C17orf86. [provided by RefSeq, Feb 2011]
The protein encoded by this gene belongs to the SEC14 cytosolic factor family. It has similarity to yeast SEC14 and to Japanese flying squid RALBP which suggests a possible role of the gene product in an intracellular transport system. Multiple alternatively spliced transcript variants have been found for this gene; some variants represent read-through transcripts that include exons from the upstream gene C17orf86. [provided by RefSeq, Feb 2011]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Brachial plexus neuropathy | 5 | 4.708 | 2.4 |
| Nonepidermolytic palmoplantar keratoderma | 12 | 3.97 | 2.0 |
| interleukin-7 receptor alpha deficiency | 16 | 3.04 | 1.5 |
| Disease | log2 FC | p |
|---|---|---|
| Rheumatoid Arthritis | 1.500 | 0.009 |
| nephrosclerosis | 1.116 | 0.000 |
| malignant mesothelioma | -1.400 | 0.000 |
| psoriasis | -1.300 | 0.004 |
| medulloblastoma | -1.500 | 0.002 |
| astrocytoma | 1.400 | 0.009 |
| medulloblastoma, large-cell | -2.500 | 0.000 |
| adrenocortical carcinoma | -1.267 | 0.000 |
| intraductal papillary-mucinous adenoma (... | -1.300 | 0.006 |
| intraductal papillary-mucinous carcinoma... | -2.300 | 0.000 |
| intraductal papillary-mucinous neoplasm ... | -1.400 | 0.008 |
| interstitial cystitis | 2.400 | 0.000 |
| adult high grade glioma | -1.100 | 0.011 |
| non primary Sjogren syndrome sicca | 1.100 | 0.018 |
| subependymal giant cell astrocytoma | -1.749 | 0.010 |
| lung adenocarcinoma | -1.180 | 0.000 |
| spina bifida | -1.058 | 0.038 |
| Pick disease | 1.700 | 0.000 |
| ulcerative colitis | 2.300 | 0.000 |
| ovarian cancer | 2.400 | 0.000 |
| Species | Source |
|---|---|
| Mouse | OMA Inparanoid |
| Rat | OMA Inparanoid |
| Dog | OMA Inparanoid |
| Horse | OMA Inparanoid |
| Cow | OMA Inparanoid |
| Pig | OMA Inparanoid |
| Opossum | OMA Inparanoid |
| Chicken | OMA Inparanoid |
| Anole lizard | OMA Inparanoid |
| Xenopus | OMA Inparanoid |
| PMID | Text |
|---|---|
| 25701228 | a markedly different role of SEC14L1 in TMPSSR2:ERG-negative and TMPSSR2:ERG-positive prostate cancers |
| 23843640 | These findings suggest that SEC14L1 functions as a novel negative regulator of RIG-I-mediated antiviral signaling by preventing RIG-I interaction with the downstream effector. |
| 23083832 | TCEB1 and SELC14L1 are good candidate markers for predicting prognosis and progression of prostate cancer. |
| 22374094 | Sec14 and Sec14 like proteins form central conduits to integrate multiple aspects of lipid metabolism with productive phosphoinositide signaling. (Review) |
| 18187620 | Knockdown of SEC14-like 1 (SEC14L1) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells |
MVQKYQSPVRVYKYPFELIMAAYERRFPTCPLIPMFVGSDTVNEFKSEDGAIHVIERRCKLDVDAPRLLK 1 - 70 KIAGVDYVYFVQKNSLNSRERTLHIEAYNETFSNRVIINEHCCYTVHPENEDWTCFEQSASLDIKSFFGF 71 - 140 ESTVEKIAMKQYTSNIKKGKEIIEYYLRQLEEEGITFVPRWSPPSITTSSETSSSSSKKQAASMAVVIPE 141 - 210 AALKEGLSGDALSSPSAPEPVVGTPDDKLDADYIKRYLGDLTPLQESCLIRLRQWLQETHKGKIPKDEHI 211 - 280 LRFLRARDFNIDKAREIMCQSLTWRKQHQVDYILETWTPPQVLQDYYAGGWHHHDKDGRPLYVLRLGQMD 281 - 350 TKGLVRALGEEALLRYVLSINEEGLRRCEENTKVFGRPISSWTCLVDLEGLNMRHLWRPGVKALLRIIEV 351 - 420 VEANYPETLGRLLILRAPRVFPVLWTLVSPFIDDNTRRKFLIYAGNDYQGPGGLLDYIDKEIIPDFLSGE 421 - 490 CMCEVPEGGLVPKSLYRTAEELENEDLKLWTETIYQSASVFKGAPHEILIQIVDASSVITWDFDVCKGDI 491 - 560 VFNIYHSKRSPQPPKKDSLGAHSITSPGGNNVQLIDKVWQLGRDYSMVESPLICKEGESVQGSHVTRWPG 561 - 630 FYILQWKFHSMPACAASSLPRVDDVLASLQVSSHKCKVMYYTEVIGSEDFRGSMTSLESSHSGFSQLSAA 631 - 700 TTSSSQSHSSSMISR 701 - 715 //
| PMID | Year | Title |
|---|---|---|
| 25701228 | 2015 | Saccharomyces cerevisiae-like 1 overexpression is frequent in prostate cancer and has markedly different effects in Ets-related gene fusion-positive and fusion-negative cancers. |
| 25378659 | 2015 | Genetic loci associated with circulating levels of very long-chain saturated fatty acids. |
| 24275569 | 2014 | An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. |
| 23843640 | 2013 | Negative regulation of RIG-I-mediated innate antiviral signaling by SEC14L1. |
| 23186163 | 2013 | Toward a comprehensive characterization of a human cancer cell phosphoproteome. |
| 23083832 | 2012 | A 12-gene expression signature is associated with aggressive histological in prostate cancer: SEC14L1 and TCEB1 genes are potential markers of progression. |
| 22814378 | 2012 | N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. |
| 22683750 | 2012 | A meta-analysis of genome-wide association studies of the electrocardiographic early repolarization pattern. |
| 22374094 | 2012 | Sec14 like PITPs couple lipid metabolism with phosphoinositide synthesis to regulate Golgi functionality. |
| 20068231 | 2010 | Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. |
| More... |
