Property Summary

NCBI Gene PubMed Count 16
PubMed Score 43.17
PubTator Score 27.87

Knowledge Summary


No data available


  Disease Sources (2)

Disease Target Count P-value
lung carcinoma 2844 3.22101218780081E-24
juvenile dermatomyositis 1189 6.8603541799458E-10
non-small cell lung cancer 2798 8.66610697906789E-10
malignant mesothelioma 3163 1.94666090597354E-9
acute quadriplegic myopathy 1157 5.18920353551425E-7
lung cancer 4473 2.31685658114108E-6
ulcerative colitis 2087 4.33370980777515E-6
pilocytic astrocytoma 3086 7.50039242165886E-6
pediatric high grade glioma 2712 3.76669235775745E-5
posterior fossa group A ependymoma 1511 4.01357698914584E-5
ovarian cancer 8492 2.92826482050038E-4
nephrosclerosis 329 4.8316280153037E-4
autosomal dominant Emery-Dreifuss muscular dystrophy 499 5.42460917551972E-4
osteosarcoma 7933 5.68955940653573E-4
intraductal papillary-mucinous adenoma (IPMA) 2956 9.42002940306686E-4
lung adenocarcinoma 2714 0.00129976224631161
primary Sjogren syndrome 789 0.0017631214747001
pancreatic cancer 2300 0.00204779640043141
primary pancreatic ductal adenocarcinoma 1271 0.00283928037255626
cystic fibrosis and chronic rhinosinusitis 213 0.00437865882737864
psoriasis 6685 0.00959108382229969
chronic lymphocytic leukemia 244 0.0139201421988273
dermatomyositis 967 0.0176516871131661
glioblastoma 5572 0.018153731346103
Waldenstrons macroglobulinemia 765 0.0215159184082589
sarcoidosis 368 0.0327843187224401
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.0453377081561572
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.0496086232571584
Disease Target Count Z-score Confidence
Osteomyelitis 20 3.358 1.7
X-linked hyper IgM syndrome 5 3.318 1.7



Accession Q92478 B2R9U1 Q8IZE9 Q9BS74 Q9UQB4
Symbols AICL


  Ortholog (3)

Species Source
Chimp OMA EggNOG
Dog OMA EggNOG Inparanoid
Pig OMA EggNOG Inparanoid

Gene RIF (6)

26418160 Data suggest that vascular smooth muscle cells (VSMCs) stimulate platelets through platelet receptor CLEC-2, possibly leading to thrombus formation after plaque erosion.
25462818 Lipid rafts do not directly contribute to CLEC-2 receptor activation in platelets.
23929856 our data report a previously unrecognized regulatory circuit enabling autonomous control of human NK cell responses via the NKp80-AICL axis.
20663776 expressed in primary liver cancers
20237496 Observational study of gene-disease association. (HuGE Navigator)
18922855 NKp80 is expressed on a highly responsive subset of effector memory CD8 T cells with an inflammatory NK-like phenotype and promotes T-cell responses toward AICL-expressing cells.

AA Sequence

KWICRKRIH                                                                 141 - 149

Text Mined References (18)

PMID Year Title
26418160 2015 Vascular Smooth Muscle Cells Stimulate Platelets and Facilitate Thrombus Formation through Platelet CLEC-2: Implications in Atherothrombosis.
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
25462818 2015 C-type lectin like receptor 2 (CLEC-2) signals independently of lipid raft microdomains in platelets.
23929856 2013 Genetically coupled receptor-ligand pair NKp80-AICL enables autonomous control of human NK cell responses.
20663776 2010 Tumor cells of non-hematopoietic and hematopoietic origins express activation-induced C-type lectin, the ligand for killer cell lectin-like receptor F1.
20237496 2010 New genetic associations detected in a host response study to hepatitis B vaccine.
18922855 2009 NKp80 defines and stimulates a reactive subset of CD8 T cells.
18029348 2008 Toward a confocal subcellular atlas of the human proteome.
16712791 2006 Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).