RAPGEF4
Rap guanine nucleotide exchange factor 4
Protein Summary
Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2 (By similarity).
- ENST00000397081
- ENSP00000380271
- ENSG00000091428
- ENST00000397087
- ENSP00000380276
- ENST00000538974
- ENSP00000440135
- ENST00000540783
- ENSP00000440250
- CGEF2
- EPAC2
- EPAC
- CGEF2
- EPAC2
- EPAC 2
- Nbla00496
- CAMP-GEFII
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 1 | ||
molecular function | 0.91 | ||
transcription factor perturbation | 0.8 | ||
PubMedID | 0.78 | ||
biological process | 0.73 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 494.75 (req: < 5)
Gene RIFs: 35 (req: <= 3)
Antibodies: 151 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 494.75 (req: >= 5)
Gene RIFs: 35 (req: > 3)
Antibodies: 151 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 14
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0