Property Summary

NCBI Gene PubMed Count 14
PubMed Score 201.59
PubTator Score 24.96

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (2)

Disease Target Count P-value
lung adenocarcinoma 2714 4.6729203205179E-7
lung cancer 4473 5.70533000981674E-6
intraductal papillary-mucinous carcinoma (IPMC) 2988 4.48783062673746E-4
psoriasis 6685 5.93514185148755E-4
interstitial cystitis 2299 8.51108444078738E-4
medulloblastoma, large-cell 6234 0.0010532314119219
osteosarcoma 7933 0.00109104138158418
intraductal papillary-mucinous adenoma (IPMA) 2956 0.00120426579655266
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.00126273113140487
active Crohn's disease 918 0.00697708267583696
active ulcerative colitis 477 0.0129330638222427
Disease Target Count Z-score Confidence
Hyperopia 33 4.182 2.1

Expression

Synonym

Accession Q8WXI4 B1AQ22 D3DQ50 O75187 Q52LP1 Q53ER9 Q96DI1 Q9H883 Acyl-CoA thioesterase 11
Symbols BFIT
THEA
THEM1
STARD14

Gene

PANTHER Protein Class (2)

PDB

3FO5  

  Ortholog (11)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Opossum OMA EggNOG Inparanoid
Platypus OMA EggNOG
Chicken OMA Inparanoid
Anole lizard OMA Inparanoid
Xenopus OMA Inparanoid

Gene RIF (5)

PMID Text
22897136 The N-terminal region of human fat inducible thioesterase variant 2 constitutes a mitochondrial location signal sequence, which undergoes mitochondrion-dependent posttranslational cleavage.
20628086 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
19913121 Observational study of gene-disease association. (HuGE Navigator)
11696000 BFIT supports the transition of thermogenic brown adipose tissue towards increased metabolic activity, probably through alteration of intracellular fatty acyl-CoA concentration.

AA Sequence

MIQNVGNHLRRGLASVFSNRTSRKSALRAGNDSAMADGEGYRNPTEVQMSQLVLPCHTNQRGELSVGQLL      1 - 70
KWIDTTACLSAERHAGCPCVTASMDDIYFEHTISVGQVVNIKAKVNRAFNSSMEVGIQVASEDLCSEKQW     71 - 140
NVCKALATFVARREITKVKLKQITPRTEEEKMEHSVAAERRRMRLVYADTIKDLLANCAIQGDLESRDCS    141 - 210
RMVPAEKTRVESVELVLPPHANHQGNTFGGQIMAWMENVATIAASRLCRAHPTLKAIEMFHFRGPSQVGD    211 - 280
RLVLKAIVNNAFKHSMEVGVCVEAYRQEAETHRRHINSAFMTFVVLDADDQPQLLPWIRPQPGDGERRYR    281 - 350
EASARKKIRLDRKYIVSCKQTEVPLSVPWDPSNQVYLSYNNVSSLKMLVAKDNWVLSSEISQVRLYTLED    351 - 420
DKFLSFHMEMVVHVDAAQAFLLLSDLRQRPEWDKHYRSVELVQQVDEDDAIYHVTSPALGGHTKPQDFVI    421 - 490
LASRRKPCDNGDPYVIALRSVTLPTHRETPEYRRGETLCSGFCLWREGDQLTKCCWVRVSLTELVSASGF    491 - 560
YSWGLESRSKGRRSDGWNGKLAGGHLSTLKAIPVAKINSRFGYLQDT                           561 - 607
//

Text Mined References (16)

PMID Year Title
22897136 2012 Human brown fat inducible thioesterase variant 2 cellular localization and catalytic function.
21738568 2011 Comparative structural analysis of lipid binding START domains.
20628086 2010 Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
20470824 2010 Functional and structural properties of mammalian acyl-coenzyme A thioesterases.
20379614 Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
19913121 2009 Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
19056867 2009 Large-scale proteomics and phosphoproteomics of urinary exosomes.
16710414 2006 The DNA sequence and biological annotation of human chromosome 1.
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
16103133 2005 A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases.
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