Tbio SOCS4 Suppressor of cytokine signaling 4

Protein Summary

Description

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR. The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS), also known as STAT-induced STAT inhibitor (SSI), protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q8WXH5
• SOCS-4

Gene Name

• SOCS4

Ensembl ID

• ENST00000339298
• ENSP00000341327
• ENSG00000180008
• ENST00000395472
• ENSP00000378855
• ENST00000555846
• ENSP00000452522

Symbol

• SOCS7
• SOCS7

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
microRNA	0.86
histone modification site profile	0.85
biological process	0.78
virus perturbation	0.76
protein domain	0.73

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / Kinase Modulator / Suppressor Of Cytokine Signaling 4

DTO Classes

Protein / Enzyme Modulator / Kinase Modulator / Suppressor Of Cytokine Signaling 4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.31   (req: < 5)

Gene RIFs: 16   (req: <= 3)

Antibodies: 264   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.31   (req: >= 5)

Gene RIFs: 16   (req: > 3)

Antibodies: 264   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0