DEDD2
DNA-binding death effector domain-containing protein 2
Protein Summary
May play a critical role in death receptor-induced apoptosis and may target CASP8 and CASP10 to the nucleus. May regulate degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3. This gene encodes a nuclear-localized protein containing a death effector domain (DED). The encoded protein may regulate the trafficking of caspases and other proteins into the nucleus during death receptor-induced apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
- ENST00000336034
- ENSP00000336972
- ENSG00000160570
- ENST00000595337
- ENSP00000470082
- ENST00000596251
- ENSP00000471512
- FLAME3
- FLAME3
- FLAME-3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor binding site profile | 0.81 | ||
biological process | 0.79 | ||
cell type or tissue | 0.76 | ||
tissue sample | 0.75 | ||
kinase perturbation | 0.71 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 11.48 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 194 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 11.48 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 194 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0