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Tbio
METTL21A
Protein N-lysine methyltransferase METTL21A

Protein Summary
Description
Protein-lysine methyltransferase that selectively trimethylates residues in heat shock protein 70 (HSP70) family members. Contributes to the in vivo trimethylation of Lys residues in HSPA1 and HSPA8. In vitro methylates 'Lys-561' in HSPA1, 'Lys-564' in HSPA2, 'Lys-585' in HSPA5, 'Lys-563' in HSPA6 and 'Lys-561' in HSPA8.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000406927
  • ENSP00000385481
  • ENSG00000144401
  • ENST00000411432
  • ENSP00000415115
  • ENST00000425132
  • ENSP00000400730
  • ENST00000426075
  • ENSP00000403317
  • ENST00000442521
  • ENSP00000392062
  • ENST00000448007
  • ENSP00000407622
  • ENST00000458426
  • ENSP00000389684

Symbol
  • FAM119A
  • HCA557B
  • FAM119A
  • HCA557b
  • HSPA-KMT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.85
histone modification site profile
0.84
transcription factor binding site profile
0.83
transcription factor perturbation
0.68
transcription factor
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.46   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 143   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.46   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 143   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0