Tchem SLC5A11 Sodium/myo-inositol cotransporter 2

Protein Summary

Description

Involved in the sodium-dependent cotransport of myo-inositol (MI) with a Na(+):MI stoichiometry of 2:1. Exclusively responsible for apical MI transport and absorption in intestine. Also can transport D-chiro-inositol (DCI) but not L-fructose. Exhibits stereospecific cotransport of both D-glucose and D-xylose. May induce apoptosis through the TNF-alpha, PDCD1 pathway. May play a role in the regulation of MI concentration in serum, involving reabsorption in at least the proximal tubule of the kidney. Cotransporters, such as SLC5A11, represent a major class of proteins that make use of ion gradients to drive active transport for the cellular accumulation of nutrients, neurotransmitters, osmolytes, and ions Roll et al. (2002) [PubMed 12039040].[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q8WWX8
• B7Z329
• Q05BF1
• Q6PF02
• Q6ZUW3
• Q86Y55
• Q96PP5
• Na(+)/myo-inositol cotransporter 2

Gene Name

• SLC5A11

Ensembl ID

• ENST00000347898
• ENSP00000289932
• ENSG00000158865
• ENST00000424767
• ENSP00000416782
• ENST00000449109
• ENSP00000389606
• ENST00000545376
• ENSP00000441384
• ENST00000565769
• ENSP00000457179
• ENST00000567758
• ENSP00000454401
• ENST00000568579
• ENSP00000456234
• ENST00000569071
• ENSP00000456376

Symbol

• KST1
• SLGTX
• SMIT2
• KST1
• RKST1
• SGLT6
• SMIT2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.76
transcription factor	0.71
cell line	0.66
tissue	0.61
PubMedID	0.6

Protein Classes

PANTHER Classes

Protein / Transporter / Cation Transporter / Sodium/myo-inositol Cotransporter 2

Protein / Transporter / Carbohydrate Transporter / Sodium/myo-inositol Cotransporter 2

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc5 Family Of Sodium-dependent Glucose Transporters / Sodium Myo-inositol Cotransporter Transporters / Sodium/myo-inositol Cotransporter 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.59   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 130   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.59   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1