Property Summary

NCBI Gene PubMed Count 13
PubMed Score 5.05
PubTator Score 5.89

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (2)

Disease Target Count P-value
lung carcinoma 2844 1.59620733048191E-28
non-small cell lung cancer 2798 2.73405706613612E-25
pilocytic astrocytoma 3086 1.31734087283664E-6
osteosarcoma 7933 5.8961667038474E-6
interstitial cystitis 2299 0.00106020171598037
adult high grade glioma 2148 0.00108647271421855

Expression

  Differential Expression (6)

Disease log2 FC p
osteosarcoma -2.740 0.000
non-small cell lung cancer -1.301 0.000
interstitial cystitis 1.600 0.001
adult high grade glioma 1.200 0.001
pilocytic astrocytoma 1.200 0.000
lung carcinoma -1.800 0.000

Synonym

Accession Q8WWW8 A6NHF8 E9PB44
Symbols

Gene

  Ortholog (9)

Species Source
Chimp OMA EggNOG
Macaque OMA Inparanoid
Mouse OMA Inparanoid
Horse OMA Inparanoid
Cow OMA Inparanoid
Opossum OMA Inparanoid
Platypus OMA Inparanoid
Anole lizard OMA Inparanoid
Xenopus OMA Inparanoid

Gene RIF (5)

PMID Text
20628086 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20237496 Observational study of gene-disease association. (HuGE Navigator)
19913121 Observational study of gene-disease association. (HuGE Navigator)
12640125 Hematopoiesis in mice lacking Gab3 is not impaired, macrophages develop in normal numbers and exhibit normal function, and there is no major immune deficiency in T- and B-lymphocyte responses to protein antigens or during viral infection.
11997510 The carboxy-terminal SH3 domain of the adapter protein Mona interacts with the atypical proline-rich domain of Gab3 to mediate late signaling of the macrophage colony-stimulating factor receptor.

AA Sequence

MSAGDAVCTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVIDLSECAVWKH      1 - 70
VGPSFVRKEFQNNFVFIVKTTSRTFYLVAKTEQEMQVWVHSISQVCNLGHLEDGADSMESLSYTPSSLQP     71 - 140
SSASSLLTAHAASSSLPRDDPNTNAVATEETRSESELLFLPDYLVLSNCETGRLHHTSLPTRCDSWSNSD    141 - 210
RSLEQASFDDVFVDCLQPLPSSHLVHPSCHGSGAQEVPSSRPQAALIWSREINGPPRDHLSSSPLLESSL    211 - 280
SSTIQVDKNQGSLPCGAKELDIMSNTPPPRPPKPSHLSERRQEEWSTHSGSKKPECTLVPRRISLSGLDN    281 - 350
MRTWKADVEGQSLRHRDKRLSLNLPCRFSPMYPTASASIEDSYVPMSPQAGASGLGPHCSPDDYIPMNSG    351 - 420
SISSPLPELPANLEPPPVNRDLKPQRKSRPPPLDLRNLSIIREHASLTRTRTVPCSRTSFLSPERNGINS    421 - 490
ARFFANPVSREDEESYIEMEEHRTASSLSSGALTWTKKFSLDYLALDFNSASPAPMQQKLLLSEEQRVDY    491 - 560
VQVDEQKTQALQSTKQEWTDERQSKV                                                561 - 586
//

Text Mined References (16)

PMID Year Title
23431498 2013 Gab docking proteins in cardiovascular disease, cancer, and inflammation.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
22163099 2011 Grb2-associated binding (Gab) proteins in hematopoietic and immune cell biology.
20628086 2010 Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
20237496 2010 New genetic associations detected in a host response study to hepatitis B vaccine.
19913121 2009 Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
19430480 2009 Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.
17567994 2007 Prominent use of distal 5' transcription start sites and discovery of a large number of additional exons in ENCODE regions.
16386802 2006 The multiple function of Grb2 associated binder (Gab) adaptor/scaffolding protein in immune cell signaling.
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
More...