Tbio TCP11 T-complex protein 11 homolog

Protein Summary

Description

Plays a role in the process of sperm capacitation and acrosome reactions. Probable receptor for the putative fertilization-promoting peptide (FPP) at the sperm membrane that may modulate the activity of the adenylyl cyclase cAMP pathway.

Uniprot Accession IDs

• Q8WWU5
• B2RCE9
• B3KQ27
• B7Z7B5
• B7Z7G1
• B7Z7H4
• B7Z7S8
• E7EP29
• J3KNG1
• Q8NF85
• Q9NQZ9
• Q9NR39

Gene Name

• TCP11

Ensembl ID

• ENST00000244645
• ENSP00000244645
• ENSG00000124678
• ENST00000311875
• ENSP00000308708
• ENST00000373974
• ENSP00000363085
• ENST00000373979
• ENSP00000363091
• ENST00000412155
• ENSP00000402816
• ENST00000418521
• ENSP00000415320
• ENST00000444780
• ENSP00000404479
• ENST00000512012
• ENSP00000425995
• ENST00000611141
• ENSP00000478603

Symbol

• FPPR
• D6S230E

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor	0.65
transcription factor binding site profile	0.62
PubMedID	0.52
phenotype	0.47
tissue sample	0.47

Protein Classes

PANTHER Classes

Protein / Receptor / T-complex Protein 11 Homolog

DTO Classes

Protein / Receptor / T-complex Protein 11 Homolog

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.66   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 95   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.66   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 95   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0