| Tbio | Solute carrier family 13 member 3 |
High-affinity sodium-dicarboxylate cotransporter that accepts a range of substrates with 4-5 carbon atoms. The stoichiometry is probably 3 Na(+) for 1 divalent succinate.
Mammalian sodium-dicarboxylate cotransporters transport succinate and other Krebs cycle intermediates. They fall into 2 categories based on their substrate affinity: low affinity and high affinity. Both the low- and high-affinity transporters play an important role in the handling of citrate by the kidneys. The protein encoded by this gene represents the high-affinity form. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, although the full-length nature of some of them have not been characterized yet. [provided by RefSeq, Jul 2008]
Mammalian sodium-dicarboxylate cotransporters transport succinate and other Krebs cycle intermediates. They fall into 2 categories based on their substrate affinity: low affinity and high affinity. Both the low- and high-affinity transporters play an important role in the handling of citrate by the kidneys. The protein encoded by this gene represents the high-affinity form. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, although the full-length nature of some of them have not been characterized yet. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| medulloblastoma, large-cell | 6241 | 8.5e-07 |
| sonic hedgehog group medulloblastoma | 467 | 4.0e-05 |
| osteosarcoma | 7950 | 4.2e-04 |
| nephrosclerosis | 333 | 1.0e-02 |
| gastric carcinoma | 807 | 1.1e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Canavan disease | 10 | 3.757 | 1.9 |
| Diastrophic dysplasia | 21 | 3.405 | 1.7 |
| Axenfeld-Rieger syndrome | 14 | 3.244 | 1.6 |
| Microphthalmia with limb anomalies | 40 | 3.064 | 1.5 |
| Disease | log2 FC | p |
|---|---|---|
| gastric carcinoma | -1.200 | 1.1e-02 |
| medulloblastoma, large-cell | 1.500 | 8.5e-07 |
| nephrosclerosis | -1.923 | 1.0e-02 |
| osteosarcoma | 1.123 | 4.2e-04 |
| sonic hedgehog group medulloblastoma | -1.200 | 4.0e-05 |
MAALAAAAKKVWSARRLLVLLFTPLALLPVVFALPPKEGRCLFVILLMAVYWCTEALPLSVTALLPIVLF 1 - 70 PFMGILPSNKVCPQYFLDTNFLFLSGLIMASAIEEWNLHRRIALKILMLVGVQPARLILGMMVTTSFLSM 71 - 140 WLSNTASTAMMLPIANAILKSLFGQKEVRKDPSQESEENTAAVRRNGLHTVPTEMQFLASTEAKDHPGET 141 - 210 EVPLDLPADSRKEDEYRRNIWKGFLISIPYSASIGGTATLTGTAPNLILLGQLKSFFPQCDVVNFGSWFI 211 - 280 FAFPLMLLFLLAGWLWISFLYGGLSFRGWRKNKSEIRTNAEDRARAVIREEYQNLGPIKFAEQAVFILFC 281 - 350 MFAILLFTRDPKFIPGWASLFNPGFLSDAVTGVAIVTILFFFPSQRPSLKWWFDFKAPNTETEPLLTWKK 351 - 420 AQETVPWNIILLLGGGFAMAKGCEESGLSVWIGGQLHPLENVPPALAVLLITVVIAFFTEFASNTATIII 421 - 490 FLPVLAELAIRLRVHPLYLMIPGTVGCSFAFMLPVSTPPNSIAFASGHLLVKDMVRTGLLMNLMGVLLLS 491 - 560 LAMNTWAQTIFQLGTFPDWADMYSVNVTALPPTLANDTFRTL 561 - 602 //
