Property Summary

NCBI Gene PubMed Count 15
PubMed Score 2.87
PubTator Score 2.67

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (2)

Disease Target Count P-value
posterior fossa group A ependymoma 1511 1.51542306321244E-17
glioblastoma 5572 1.58101901349953E-9
medulloblastoma 1524 2.47862668357242E-9
pilocytic astrocytoma 3086 2.73028036546347E-9
atypical teratoid / rhabdoid tumor 4369 1.21868809203044E-8
medulloblastoma, large-cell 6234 1.86213911531442E-8
primitive neuroectodermal tumor 3031 3.05784197705626E-8
osteosarcoma 7933 2.24961441678991E-6
pituitary cancer 1972 3.77318882044615E-6
adult high grade glioma 2148 1.75776624941987E-5
lung cancer 4473 1.15189673425043E-4
Down syndrome 548 0.00149856108276308
astrocytic glioma 2241 0.00177437560741615
oligodendroglioma 2849 0.0103010209696035
cutaneous lupus erythematosus 1056 0.0248130282109852

Expression

  Differential Expression (15)

Disease log2 FC p
astrocytic glioma -3.200 0.002
posterior fossa group A ependymoma -4.400 0.000
oligodendroglioma -2.800 0.010
cutaneous lupus erythematosus 1.500 0.025
glioblastoma -4.700 0.000
osteosarcoma -3.225 0.000
medulloblastoma -4.700 0.000
atypical teratoid / rhabdoid tumor -4.200 0.000
medulloblastoma, large-cell -5.200 0.000
primitive neuroectodermal tumor -5.100 0.000
lung cancer -1.800 0.000
adult high grade glioma -3.700 0.000
pilocytic astrocytoma -3.600 0.000
pituitary cancer 2.300 0.000
Down syndrome -1.100 0.001

Synonym

Accession Q8WWN9 A8K1K2 B7ZL78 B7ZL80 O43153 Q5HYL8
Symbols PIP3-E

Gene

PANTHER Protein Class (2)

  Ortholog (7)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA Inparanoid
Rat OMA Inparanoid
Horse OMA Inparanoid
Opossum OMA EggNOG
Anole lizard OMA Inparanoid

Gene RIF (7)

PMID Text
22085542 CNK3 and IPCEF1 produce a single protein that is required for HGF dependent Arf6 activation and migration.
20628086 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
20016009 protein-protein interaction mediated by ARNO coiled-coil domain required for ARNO induced motility; coiled-coil domain promotes assembly of multiprotein complex containing ARNO and Dock180; assembly of complex requires coiled-coil domain, GRASP and IPCEF
19913121 Observational study of gene-disease association. (HuGE Navigator)
17067457 PTEN may down-regulate the expression of PIP3, and then down-regulate the expression of cyclin D1, which leads to the suppression of cell growth.
12920129 IPCEF1 increases the in vitro and in vivo stimulation of ARFGTP formation by cytohesin 2

AA Sequence

MTSYMAIDGSALVPLRQKPRRKTQGFLTMSRRRISCKDLGHADCQGWLYKKKEKGSFLSNKWKKFWVILK      1 - 70
GSSLYWYSNQMAEKADGFVNLPDFTVERASECKKKHAFKISHPQIKTFYFAAENVQEMNVWLNKLGSAVI     71 - 140
HQESTTKDEECYSESEQEDPEIAAETPPPPHASQTQSLTAQQASSSSPSLSGTSYSFSSLENTVKTPSSF    141 - 210
PSSLSKERQSLPDTVNSLSAAEDEGQPITFAVQVHSPVPSEAGIHKALENSFVTSESGFLNSLSSDDTSS    211 - 280
LSSNHDHLTVPDKPAGSKIMDKEETKVSEDDEMEKLYKSLEQASLSPLGDRRPSTKKELRKSFVKRCKNP    281 - 350
SINEKLHKIRTLNSTLKCKEHDLAMINQLLDDPKLTARKYREWKVMNTLLIQDIYQQQRASPAPDDTDDT    351 - 420
PQELKKSPSSPSVENSI                                                         421 - 437
//

Text Mined References (18)

PMID Year Title
24292274 2014 A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia.
22085542 2012 CNK3 and IPCEF1 produce a single protein that is required for HGF dependent Arf6 activation and migration.
20628086 2010 Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
20379614 Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
20016009 2010 GRASP and IPCEF promote ARF-to-Rac signaling and cell migration by coordinating the association of ARNO/cytohesin 2 with Dock180.
19913121 2009 Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
19756519 2009 Peripheral nerve injury up-regulates expression of interactor protein for cytohesin exchange factor 1 (IPCEF1) mRNA in rat dorsal root ganglion.
17974005 2007 The full-ORF clone resource of the German cDNA Consortium.
17067457 2006 [Expression of tumor suppressor gene PTEN, PIP3 and cyclin D1 in oral squamous cell carcinoma and their correlations].
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
More...