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Tbio
CKAP2
Cytoskeleton-associated protein 2

Protein Summary
Description
Possesses microtubule stabilizing properties. Involved in regulating aneuploidy, cell cycling, and cell death in a p53/TP53-dependent manner (By similarity). This gene encodes a cytoskeleton-associated protein that stabalizes microtubules and plays a role in the regulation of cell division. The encoded protein is itself regulated through phosphorylation at multiple serine and threonine residues. There is a pseudogene of this gene on chromosome 14. Alternative splicing results in multiple transcript variations. [provided by RefSeq, Nov 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000258607
  • ENSP00000258607
  • ENSG00000136108
  • ENST00000378034
  • ENSP00000367273
  • ENST00000378037
  • ENSP00000367276
  • ENST00000490903
  • ENSP00000417830

Symbol
  • LB1
  • TMAP
  • LB1
  • TMAP
  • se20-10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.8
kinase perturbation
0.76
histone modification site profile
0.75
cellular component
0.72
tissue sample
0.72


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 476.06   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 114   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 476.06   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 114   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0