Property Summary

NCBI Gene PubMed Count 23
PubMed Score 17.95
PubTator Score 9.30

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (5)

Disease Target Count P-value
non-small cell lung cancer 2798 1.89631767580946E-27
ependymoma 2514 3.97540928278815E-14
lung carcinoma 2844 1.38866046287621E-13
lung adenocarcinoma 2714 1.73474012485335E-12
atypical teratoid / rhabdoid tumor 4369 5.77781167064109E-8
medulloblastoma 1524 1.77918587987401E-7
Amyotrophic Lateral Sclerosis 432 9.46137597484581E-7
glioblastoma 5572 2.9856773472032E-6
lung cancer 4473 3.61502035423655E-6
pilocytic astrocytoma 3086 5.61456006614281E-6
intraductal papillary-mucinous adenoma (IPMA) 2956 7.01252074212844E-6
primitive neuroectodermal tumor 3031 1.12158876932273E-5
intraductal papillary-mucinous carcinoma (IPMC) 2988 2.65404358933573E-5
pancreatic cancer 2300 2.71031463194141E-5
osteosarcoma 7933 4.80400554329355E-5
pediatric high grade glioma 2712 8.54837962414521E-5
medulloblastoma, large-cell 6234 2.97661107727611E-4
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.00319432319392679
interstitial lung disease 292 0.0071355815397054
astrocytic glioma 2241 0.0259342657686061
oligodendroglioma 2849 0.0373723669773087
spina bifida 1064 0.0398657641750647
pancreatic ductal adenocarcinoma liver metastasis 1795 0.0433445082935826
chronic rhinosinusitis 512 0.0464935569305093
cystic fibrosis and chronic rhinosinusitis 213 0.048236643599538
Disease Target Count Z-score Confidence
Carcinoma 2147 0.0 1.0
Disease Target Count Z-score Confidence
Refractive error 43 0.0 1.0
Type 1 diabetes mellitus 104 0.0 2.0
Disease Target Count Z-score Confidence
Emery-Dreifuss muscular dystrophy 24 4.728 2.4

Expression

Synonym

Accession Q8WWI1 E9PLH4 O15462 O95346 Q5TBK6 Q9UKC1 Q9UQM5 Q9Y6A7 LMO-7
Symbols LOMP
FBX20
FBXO20

Gene

PDB

2EAQ  

  Ortholog (12)

Species Source
Chimp OMA EggNOG
Macaque OMA Inparanoid
Mouse OMA Inparanoid
Rat OMA Inparanoid
Dog OMA Inparanoid
Horse OMA Inparanoid
Cow OMA Inparanoid
Opossum OMA EggNOG Inparanoid
Chicken OMA Inparanoid
Anole lizard OMA Inparanoid
Xenopus OMA Inparanoid
Zebrafish OMA Inparanoid

Gene RIF (5)

PMID Text
26786059 Data suggest that Lmo7 is localized at the perinuclear region and in fibril-like structures along subsarcolemma of human skeletal myoblasts whereas in human myotubes Lmo7 is found diffuse throughout the cytoplasm.
21670154 show that LMO7 is upregulated in the stroma of invasive breast carcinoma in a manner that correlates with the increased expression of serum response factor target genes
21525034 functional interaction between emerin and Lmo7 is crucial for temporally regulating the expression of key myogenic differentiation genes.
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
17067998 Lmo7 positively regulates many EDMD-relevant genes (including emerin), and is feedback-regulated by binding to emerin.

AA Sequence

MKKIRICHIFTFYSWMSYDVLFQRTELGALEIWRQLICAHVCICVGWLYLRDRVCSKKDIILRTEQNSGR      1 - 70
TILIKAVTEKNFETKDFRASLENGVLLCDLINKLKPGVIKKINRLSTPIAGLDNINVFLKACEQIGLKEA     71 - 140
QLFHPGDLQDLSNRVTVKQEETDRRVKNVLITLYWLGRKAQSNPYYNGPHLNLKAFENLLGQALTKALED    141 - 210
SSFLKRSGRDSGYGDIWCPERGEFLAPPRHHKREDSFESLDSLGSRSLTSCSSDITLRGGREGFESDTDS    211 - 280
EFTFKMQDYNKDDMSYRRISAVEPKTALPFNRFLPNKSRQPSYVPAPLRKKKPDKHEDNRRSWASPVYTE    281 - 350
ADGTFSSNQRRIWGTNVENWPTVQGTSKSSCYLEEEKAKTRSIPNIVKDDLYVRKLSPVMPNPGNAFDQF    351 - 420
LPKCWTPEDVNWKRIKRETYKPWYKEFQGFSQFLLLQALQTYSDDILSSETHTKIDPTSGPRLITRRKNL    421 - 490
SYAPGYRRDDLEMAALDPDLENDDFFVRKTGVFHANPYVLRAFEDFRKFSEQDDSVERDIILQCREGELV    491 - 560
LPDLEKDDMIVRRIPAQKKEVPLSGAPDRYHPVPFPEPWTLPPEIQAKFLCVFERTCPSKEKSNSCRILV    561 - 630
PSYRQKKDDMLTRKIQSWKLGTTVPPISFTPGPCSEADLKRWEAIREASRLRHKKRLMVERLFQKIYGEN    631 - 700
GSKSMSDVSAEDVQNLRQLRYEEMQKIKSQLKEQDQKWQDDLAKWKDRRKSYTSDLQKKKEEREEIEKQA    701 - 770
LEKSKRSSKTFKEMLQDRESQNQKSTVPSRRRMYSFDDVLEEGKRPPTMTVSEASYQSERVEEKGATYPS    771 - 840
EIPKEDSTTFAKREDRVTTEIQLPSQSPVEEQSPASLSSLRSRSTQMESTRVSASLPRSYRKTDTVRLTS    841 - 910
VVTPRPFGSQTRGISSLPRSYTMDDAWKYNGDVEDIKRTPNNVVSTPAPSPDASQLASSLSSQKEVAATE    911 - 980
EDVTRLPSPTSPFSSLSQDQAATSKATLSSTSGLDLMSESGEGEISPQREVSRSQDQFSDMRISINQTPG    981 - 1050
KSLDFGFTIKWDIPGIFVASVEAGSPAEFSQLQVDDEIIAINNTKFSYNDSKEWEEAMAKAQETGHLVMD   1051 - 1120
VRRYGKAGSPETKWIDATSGIYNSEKSSNLSVTTDFSESLQSSNIESKEINGIHDESNAFESKASESISL   1121 - 1190
KNLKRRSQFFEQGSSDSVVPDLPVPTISAPSRWVWDQEEERKRQERWQKEQDRLLQEKYQREQEKLREEW   1191 - 1260
QRAKQEAERENSKYLDEELMVLSSNSMSLTTREPSLATWEATWSEGSKSSDREGTRAGEEERRQPQEEVV   1261 - 1330
HEDQGKKPQDQLVIERERKWEQQLQEEQEQKRLQAEAEEQKRPAEEQKRQAEIERETSVRIYQYRRPVDS   1331 - 1400
YDIPKTEEASSGFLPGDRNKSRSTTELDDYSTNKNGNNKYLDQIGNMTSSQRRSKKEQVPSGAELERQQI   1401 - 1470
LQEMRKRTPLHNDNSWIRQRSASVNKEPVSLPGIMRRGESLDNLDSPRSNSWRQPPWLNQPTGFYASSSV   1471 - 1540
QDFSRPPPQLVSTSNRAYMRNPSSSVPPPSAGSVKTSTTGVATTQSPTPRSHSPSASQSGSQLRNRSVSG   1541 - 1610
KRICSYCNNILGKGAAMIIESLGLCYHLHCFKCVACECDLGGSSSGAEVRIRNHQLYCNDCYLRFKSGRP   1611 - 1680
TAM                                                                      1681 - 1683
//

Text Mined References (36)

PMID Year Title
26786059 2016 Knockdown of Lmo7 inhibits chick myogenesis.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
23761726 2013 Interrogation of the platelet-derived growth factor receptor alpha locus and corneal astigmatism in Australians of Northern European ancestry: results of a genome-wide association study.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
22814378 2012 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
21980299 2011 A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci.
21670154 2011 LMO7 mediates cell-specific activation of the Rho-myocardin-related transcription factor-serum response factor pathway and plays an important role in breast cancer cell migration.
21525034 2011 Emerin inhibits Lmo7 binding to the Pax3 and MyoD promoters and expression of myoblast proliferation genes.
21423176 2011 Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for ?-Pix in negative regulation of focal adhesion maturation.
21406692 2011 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
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