Tbio NRG4 Pro-neuregulin-4, membrane-bound isoform

Protein Summary

Description

Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors (By similarity). The neuregulins, including NRG4, activate type-1 growth factor receptors (see EGFR; MIM 131550) to initiating cell-to-cell signaling through tyrosine phosphorylation (Harari et al., 1999 [PubMed 10348342]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q8WWG1
• A6NIE8
• Pro-NRG4

Gene Name

• NRG4

Ensembl ID

• ENST00000394907
• ENSP00000378367
• ENSG00000169752
• ENST00000566417
• ENSP00000457335

Symbol

• HRG4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.62
tissue sample	0.55
microRNA	0.53
tissue	0.52
cell line	0.5

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Growth Factor / Pro-neuregulin-4, Membrane-bound Isoform

DTO Classes

Protein / Signaling / Growth Factor / Pro-neuregulin-4, Membrane-bound Isoform

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.5   (req: < 5)

Gene RIFs: 28   (req: <= 3)

Antibodies: 199   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.5   (req: >= 5)

Gene RIFs: 28   (req: > 3)

Antibodies: 199   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0