Property Summary

NCBI Gene PubMed Count 19
Grant Count 9
R01 Count 8
Funding $483,170.3
PubMed Score 16.76
PubTator Score 15.01

Knowledge Summary


No data available


  Differential Expression (3)

Disease log2 FC p
osteosarcoma -1.427 0.000
gastric carcinoma -1.100 0.008
mucosa-associated lymphoid tissue lympho... -1.363 0.006

 MGI Term (1)

Gene RIF (11)

26476959 Nrg4 might have a protective role in the development of Non-alcoholic fatty liver disease (NAFLD).
25401691 results establish Nrg4 as a brown fat-enriched endocrine factor with therapeutic potential for the treatment of obesity-associated disorders, including type 2 diabetes and nonalcoholic fatty liver disease (NAFLD).
25216938 NRG4 and its receptor ErbB4 are present in human breast milk and developing human intestine, respectively. Thus, NRG4-ErbB4 signaling may be a novel pathway for therapeutic intervention or prevention in NEC.
23033483 Pharmacological inhibition of PI3K/Akt signaling reversed the anti-apoptotic effects of NRG4, confirming the role of this cascade in NRG4-induced cell survival
21805036 The recombinant neuregulin 4 induced the tyrosine phosphorylation of HER4.
20628086 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19913121 Observational study of gene-disease association. (HuGE Navigator)
17962208 NRG4 was positive in almost all breast cancers studied.
17684490 describes a novel splice variant of the NRG4 gene, NRG4A2, which encodes a C-terminal region containing a predicted type I PDZ-binding peptide
17545517 NRG4 overexpression is associated with advanced-stage prostate cancer

AA Sequence


Text Mined References (20)

PMID Year Title
26476959 2015 A case-control study: Association between serum neuregulin 4 level and non-alcoholic fatty liver disease.
25416956 2014 A proteome-scale map of the human interactome network.
25401691 2014 The brown fat-enriched secreted factor Nrg4 preserves metabolic homeostasis through attenuation of hepatic lipogenesis.
25216938 2014 The ErbB4 ligand neuregulin-4 protects against experimental necrotizing enterocolitis.
23263486 2013 Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.
23222517 2012 Seventy-five genetic loci influencing the human red blood cell.
23033483 2012 Neuregulin-4 is a survival factor for colon epithelial cells both in culture and in vivo.
21805036 The role of neuregulin4 and HER4 in gastrointestinal malignant lymphoma.
21516116 2011 Next-generation sequencing to generate interactome datasets.
20628086 2010 Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.