| Tbio | Protein POF1B |
Plays a key role in the organization of epithelial monolayers by regulating the actin cytoskeleton. May be involved in ovary development.
Premature ovarian failure (POF) is characterized by primary or secondary amenorrhea in women less than 40 years old. Two POF susceptibility regions called "POF1" and "POF2" have been identified by breakpoint mapping of X-autosome translocations. POF1 extends from Xq21-qter while POF2 extends from Xq13.3 to Xq21.1. This gene, POF1B, resides in the POF2 region. This gene is expressed at trace levels in mouse prenatal ovary and is barely detectable or absent from adult ovary, in human and in the mouse respectively. This gene's expression is restricted to epithelia with its highest expression in the epidermis, and oro-pharyngeal and gastro-intestinal tracts. The protein encoded by this gene binds non-muscle actin filaments. The role this gene may play in the etiology of premature ovarian failure remains to be determined. [provided by RefSeq, Jan 2010]
Premature ovarian failure (POF) is characterized by primary or secondary amenorrhea in women less than 40 years old. Two POF susceptibility regions called "POF1" and "POF2" have been identified by breakpoint mapping of X-autosome translocations. POF1 extends from Xq21-qter while POF2 extends from Xq13.3 to Xq21.1. This gene, POF1B, resides in the POF2 region. This gene is expressed at trace levels in mouse prenatal ovary and is barely detectable or absent from adult ovary, in human and in the mouse respectively. This gene's expression is restricted to epithelia with its highest expression in the epidermis, and oro-pharyngeal and gastro-intestinal tracts. The protein encoded by this gene binds non-muscle actin filaments. The role this gene may play in the etiology of premature ovarian failure remains to be determined. [provided by RefSeq, Jan 2010]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Premature Ovarian Failure 2b | 1 | 0.0 | 0.0 |
| Disease | Target Count | P-value |
|---|---|---|
| lung carcinoma | 2843 | 7.8e-17 |
| periodontitis | 293 | 1.6e-15 |
| non-small cell lung cancer | 2890 | 7.4e-08 |
| pancreatic cancer | 2398 | 1.0e-05 |
| lung cancer | 4740 | 2.2e-04 |
| Atopic dermatitis | 952 | 4.1e-04 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 5.3e-04 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 2.1e-03 |
| psoriasis | 6694 | 5.4e-03 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 6.5e-03 |
| interstitial cystitis | 2312 | 8.0e-03 |
| spina bifida | 1074 | 3.9e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Premature ovarian failure | 65 | 5.257 | 2.6 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Polyhydramnios | 108 | 3.278 | 1.6 |
| Ovarian dysfunction | 18 | 3.084 | 1.5 |
| Disease | log2 FC | p |
|---|---|---|
| Atopic dermatitis | -2.300 | 4.1e-04 |
| interstitial cystitis | -2.300 | 8.0e-03 |
| intraductal papillary-mucinous adenoma (... | 1.800 | 5.3e-04 |
| intraductal papillary-mucinous carcinoma... | 1.600 | 2.1e-03 |
| intraductal papillary-mucinous neoplasm ... | 1.200 | 6.5e-03 |
| lung cancer | 2.400 | 2.2e-04 |
| lung carcinoma | 2.100 | 7.8e-17 |
| non-small cell lung cancer | 1.368 | 7.4e-08 |
| pancreatic cancer | 1.500 | 1.0e-05 |
| periodontitis | -1.200 | 1.6e-15 |
| psoriasis | 1.100 | 5.4e-03 |
| spina bifida | -1.023 | 3.9e-02 |
MSSSYWSETSSSSCGTQQLPEVLQCQPQHYHCYHQSSQAQQPPEKNVVYERVRTYSGPMNKVVQALDPFN 1 - 70 SREVLSPLKTTSSYQNLVWSDHSQELHSPTLKISTCAPSTLHITQNTEQELHSPTVKLTTYPQTTIRKYV 71 - 140 VQNPEQEPLSQFLRGSHFFPGNNVIYEKTIRKVEKLNTDQGCHPQAQCHHHIIQQPQVIHSAHWQQPDSS 141 - 210 QQIQAITGNNPISTHIGNELCHSGSSQICEQVIIQDDGPEKLDPRYFGELLADLSRKNTDLYHCLLEHLQ 211 - 280 RIGGSKQDFESTDESEDIESLIPKGLSEFTKQQIRYILQMRGMSDKSLRLVLSTFSNIREELGHLQNDMT 281 - 350 SLENDKMRLEKDLSFKDTQLKEYEELLASVRANNHQQQQGLQDSSSKCQALEENNLSLRHTLSDMEYRLK 351 - 420 ELEYCKRNLEQENQNLRMQVSETCTGPMLQAKMDEIGNHYTEMVKNLRMEKDREICRLRSQLNQYHKDVS 421 - 490 KREGSCSDFQFKLHELTSLLEEKDSLIKRQSEELSKLRQEIYSSHNQPSTGGRTTITTKKYRTQYPILGL 491 - 560 LYDDYEYIPPGSETQTIVIEKTEDKYTCP 561 - 589 //
