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- Cohesin subunit SA-1
| Tbio | Cohesin subunit SA-1 |
Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis.
This gene is a member of the SCC3 family and is expressed in the nucleus. It encodes a component of cohesin, a multisubunit protein complex that provides sister chromatid cohesion along the length of a chromosome from DNA replication through prophase and prometaphase, after which it is dissociated in preparation for segregation during anaphase. [provided by RefSeq, Jul 2008]
This gene is a member of the SCC3 family and is expressed in the nucleus. It encodes a component of cohesin, a multisubunit protein complex that provides sister chromatid cohesion along the length of a chromosome from DNA replication through prophase and prometaphase, after which it is dissociated in preparation for segregation during anaphase. [provided by RefSeq, Jul 2008]
Comments
Property Summary
| NCBI Gene PubMed Count | 26 |
| Grant Count | 2,010 |
| R01 Count | 1,240 |
| Funding | $354,361,330.7 |
| PubMed Score | 274.60 |
| PubTator Score | 72.80 |
| Disease | log2 FC | p |
|---|---|---|
| astrocytoma | 1.100 | 0.000 |
| glioblastoma | 1.400 | 0.000 |
| oligodendroglioma | 1.100 | 0.000 |
| osteosarcoma | -1.608 | 0.000 |
| posterior fossa group A ependymoma | 1.500 | 0.000 |
| medulloblastoma | 2.000 | 0.000 |
| medulloblastoma, large-cell | 1.400 | 0.002 |
| primitive neuroectodermal tumor | 1.400 | 0.000 |
| diabetes mellitus | -1.200 | 0.001 |
| pediatric high grade glioma | 1.500 | 0.000 |
| pilocytic astrocytoma | 1.100 | 0.000 |
| aldosterone-producing adenoma | -1.275 | 0.008 |
| Pick disease | 1.300 | 0.000 |
| ovarian cancer | -1.600 | 0.000 |