| Tbio | Cohesin subunit SA-1 |
Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis.
This gene is a member of the SCC3 family and is expressed in the nucleus. It encodes a component of cohesin, a multisubunit protein complex that provides sister chromatid cohesion along the length of a chromosome from DNA replication through prophase and prometaphase, after which it is dissociated in preparation for segregation during anaphase. [provided by RefSeq, Jul 2008]
This gene is a member of the SCC3 family and is expressed in the nucleus. It encodes a component of cohesin, a multisubunit protein complex that provides sister chromatid cohesion along the length of a chromosome from DNA replication through prophase and prometaphase, after which it is dissociated in preparation for segregation during anaphase. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Intellectual disability | 1016 | 0.0 | 4.0 |
| Disease | Target Count | P-value |
|---|---|---|
| astrocytoma | 1146 | 1.4e-21 |
| oligodendroglioma | 2850 | 8.6e-12 |
| ovarian cancer | 8520 | 5.9e-11 |
| ependymoma | 4679 | 5.8e-10 |
| glioblastoma | 5792 | 4.4e-07 |
| Pick disease | 1894 | 5.2e-06 |
| osteosarcoma | 7950 | 1.1e-05 |
| pediatric high grade glioma | 1064 | 3.2e-05 |
| primitive neuroectodermal tumor | 3035 | 1.3e-04 |
| Astrocytoma, Pilocytic | 3081 | 1.5e-04 |
| group 3 medulloblastoma | 4104 | 7.3e-04 |
| diabetes mellitus | 1728 | 1.4e-03 |
| medulloblastoma, large-cell | 6241 | 1.7e-03 |
| aldosterone-producing adenoma | 665 | 8.1e-03 |
| Disease | log2 FC | p |
|---|---|---|
| aldosterone-producing adenoma | -1.275 | 8.1e-03 |
| astrocytoma | 1.100 | 1.4e-21 |
| Astrocytoma, Pilocytic | 1.100 | 1.5e-04 |
| diabetes mellitus | -1.200 | 1.4e-03 |
| ependymoma | 1.400 | 5.8e-10 |
| glioblastoma | 1.300 | 4.4e-07 |
| group 3 medulloblastoma | 2.000 | 7.3e-04 |
| medulloblastoma, large-cell | 1.400 | 1.7e-03 |
| oligodendroglioma | 1.100 | 8.6e-12 |
| osteosarcoma | -1.608 | 1.1e-05 |
| ovarian cancer | -1.600 | 5.9e-11 |
| pediatric high grade glioma | 1.500 | 3.2e-05 |
| Pick disease | 1.300 | 5.2e-06 |
| primitive neuroectodermal tumor | 1.400 | 1.3e-04 |
MITSELPVLQDSTNETTAHSDAGSELEETEVKGKRKRGRPGRPPSTNKKPRKSPGEKSRIEAGIRGAGRG 1 - 70 RANGHPQQNGEGEPVTLFEVVKLGKSAMQSVVDDWIESYKQDRDIALLDLINFFIQCSGCRGTVRIEMFR 71 - 140 NMQNAEIIRKMTEEFDEDSGDYPLTMPGPQWKKFRSNFCEFIGVLIRQCQYSIIYDEYMMDTVISLLTGL 141 - 210 SDSQVRAFRHTSTLAAMKLMTALVNVALNLSIHQDNTQRQYEAERNKMIGKRANERLELLLQKRKELQEN 211 - 280 QDEIENMMNSIFKGIFVHRYRDAIAEIRAICIEEIGVWMKMYSDAFLNDSYLKYVGWTLHDRQGEVRLKC 281 - 350 LKALQSLYTNRELFPKLELFTNRFKDRIVSMTLDKEYDVAVEAIRLVTLILHGSEEALSNEDCENVYHLV 351 - 420 YSAHRPVAVAAGEFLHKKLFSRHDPQAEEALAKRRGRNSPNGNLIRMLVLFFLESELHEHAAYLVDSLWE 421 - 490 SSQELLKDWECMTELLLEEPVQGEEAMSDRQESALIELMVCTIRQAAEAHPPVGRGTGKRVLTAKERKTQ 491 - 560 IDDRNKLTEHFIITLPMLLSKYSADAEKVANLLQIPQYFDLEIYSTGRMEKHLDALLKQIKFVVEKHVES 561 - 630 DVLEACSKTYSILCSEEYTIQNRVDIARSQLIDEFVDRFNHSVEDLLQEGEEADDDDIYNVLSTLKRLTS 631 - 700 FHNAHDLTKWDLFGNCYRLLKTGIEHGAMPEQIVVQALQCSHYSILWQLVKITDGSPSKEDLLVLRKTVK 701 - 770 SFLAVCQQCLSNVNTPVKEQAFMLLCDLLMIFSHQLMTGGREGLQPLVFNPDTGLQSELLSFVMDHVFID 771 - 840 QDEENQSMEGDEEDEANKIEALHKRRNLLAAFSKLIIYDIVDMHAAADIFKHYMKYYNDYGDIIKETLSK 841 - 910 TRQIDKIQCAKTLILSLQQLFNELVQEQGPNLDRTSAHVSGIKELARRFALTFGLDQIKTREAVATLHKD 911 - 980 GIEFAFKYQNQKGQEYPPPNLAFLEVLSEFSSKLLRQDKKTVHSYLEKFLTEQMMERREDVWLPLISYRN 981 - 1050 SLVTGGEDDRMSVNSGSSSSKTSSVRNKKGRPPLHKKRVEDESLDNTWLNRTDTMIQTPGPLPAPQLTST 1051 - 1120 VLRENSRPMGDQIQEPESEHGSEPDFLHNPQMQISWLGQPKLEDLNRKDRTGMNYMKVRTGVRHAVRGLM 1121 - 1190 EEDAEPIFEDVMMSSRSQLEDMNEEFEDTMVIDLPPSRNRRERAELRPDFFDSAAIIEDDSGFGMPMF 1191 - 1258 //
