| Tbio | Cohesin subunit SA-1 |
Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis.
This gene is a member of the SCC3 family and is expressed in the nucleus. It encodes a component of cohesin, a multisubunit protein complex that provides sister chromatid cohesion along the length of a chromosome from DNA replication through prophase and prometaphase, after which it is dissociated in preparation for segregation during anaphase. [provided by RefSeq, Jul 2008]
This gene is a member of the SCC3 family and is expressed in the nucleus. It encodes a component of cohesin, a multisubunit protein complex that provides sister chromatid cohesion along the length of a chromosome from DNA replication through prophase and prometaphase, after which it is dissociated in preparation for segregation during anaphase. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count |
|---|---|
| Rheumatoid Arthritis | 1171 |
| Schizophrenia | 503 |
| Disease | Target Count | P-value |
|---|---|---|
| astrocytoma | 1493 | 1.36143693805629E-21 |
| oligodendroglioma | 2849 | 8.55089569519359E-12 |
| ovarian cancer | 8492 | 5.90971701439942E-11 |
| medulloblastoma | 1524 | 6.36809426732353E-11 |
| posterior fossa group A ependymoma | 1511 | 4.18542465693345E-9 |
| Pick disease | 1893 | 5.20650826033063E-6 |
| osteosarcoma | 7933 | 1.08405658786921E-5 |
| pediatric high grade glioma | 2712 | 3.15361261667961E-5 |
| glioblastoma | 5572 | 1.09044748866885E-4 |
| primitive neuroectodermal tumor | 3031 | 1.28128795543771E-4 |
| pilocytic astrocytoma | 3086 | 1.89218759933335E-4 |
| diabetes mellitus | 1663 | 0.00143725470850936 |
| medulloblastoma, large-cell | 6234 | 0.00170383144892174 |
| aldosterone-producing adenoma | 664 | 0.0080666464374326 |
| Disease | log2 FC | p |
|---|---|---|
| astrocytoma | 1.100 | 0.000 |
| glioblastoma | 1.400 | 0.000 |
| oligodendroglioma | 1.100 | 0.000 |
| osteosarcoma | -1.608 | 0.000 |
| posterior fossa group A ependymoma | 1.500 | 0.000 |
| medulloblastoma | 2.000 | 0.000 |
| medulloblastoma, large-cell | 1.400 | 0.002 |
| primitive neuroectodermal tumor | 1.400 | 0.000 |
| diabetes mellitus | -1.200 | 0.001 |
| pediatric high grade glioma | 1.500 | 0.000 |
| pilocytic astrocytoma | 1.100 | 0.000 |
| aldosterone-producing adenoma | -1.275 | 0.008 |
| Pick disease | 1.300 | 0.000 |
| ovarian cancer | -1.600 | 0.000 |
| Species | Source |
|---|---|
| Mouse | OMA Inparanoid |
| Rat | OMA Inparanoid |
| Cow | OMA Inparanoid |
| Opossum | OMA Inparanoid |
| Anole lizard | OMA Inparanoid |
| Xenopus | OMA Inparanoid |
| PMID | Text |
|---|---|
| 24335498 | Mutations in STAG1 is associated with acute myeloid leukemia. |
| 24324008 | cohesin-SA1 and cohesin-SA2 participate in the DNA damage response |
| 23874961 | Rad21 binds to SA proteins through two SA-binding motifs on Rad21. |
| 22715410 | Nuclear import and export signals of human cohesins SA1/STAG1 and SA2/STAG2 expressed in Saccharomyces cerevisiae. |
| 19936222 | Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) |
| 19822671 | cohesin(SA1) and cohesin(SA2) are differentially required for telomere and centromere cohesion, respectively. |
| 18550811 | STAG1 (Scc3/SA1) subunit of cohesin interacts with the CCTC-binding factor CTCF bound to the c-myc insulator element. |
| 15361841 | STAG1, a novel transcriptional target for p53, mediates p53-dependent apoptosis, and might be a good candidate for next-generation gene therapy in cancer. |
MITSELPVLQDSTNETTAHSDAGSELEETEVKGKRKRGRPGRPPSTNKKPRKSPGEKSRIEAGIRGAGRG 1 - 70 RANGHPQQNGEGEPVTLFEVVKLGKSAMQSVVDDWIESYKQDRDIALLDLINFFIQCSGCRGTVRIEMFR 71 - 140 NMQNAEIIRKMTEEFDEDSGDYPLTMPGPQWKKFRSNFCEFIGVLIRQCQYSIIYDEYMMDTVISLLTGL 141 - 210 SDSQVRAFRHTSTLAAMKLMTALVNVALNLSIHQDNTQRQYEAERNKMIGKRANERLELLLQKRKELQEN 211 - 280 QDEIENMMNSIFKGIFVHRYRDAIAEIRAICIEEIGVWMKMYSDAFLNDSYLKYVGWTLHDRQGEVRLKC 281 - 350 LKALQSLYTNRELFPKLELFTNRFKDRIVSMTLDKEYDVAVEAIRLVTLILHGSEEALSNEDCENVYHLV 351 - 420 YSAHRPVAVAAGEFLHKKLFSRHDPQAEEALAKRRGRNSPNGNLIRMLVLFFLESELHEHAAYLVDSLWE 421 - 490 SSQELLKDWECMTELLLEEPVQGEEAMSDRQESALIELMVCTIRQAAEAHPPVGRGTGKRVLTAKERKTQ 491 - 560 IDDRNKLTEHFIITLPMLLSKYSADAEKVANLLQIPQYFDLEIYSTGRMEKHLDALLKQIKFVVEKHVES 561 - 630 DVLEACSKTYSILCSEEYTIQNRVDIARSQLIDEFVDRFNHSVEDLLQEGEEADDDDIYNVLSTLKRLTS 631 - 700 FHNAHDLTKWDLFGNCYRLLKTGIEHGAMPEQIVVQALQCSHYSILWQLVKITDGSPSKEDLLVLRKTVK 701 - 770 SFLAVCQQCLSNVNTPVKEQAFMLLCDLLMIFSHQLMTGGREGLQPLVFNPDTGLQSELLSFVMDHVFID 771 - 840 QDEENQSMEGDEEDEANKIEALHKRRNLLAAFSKLIIYDIVDMHAAADIFKHYMKYYNDYGDIIKETLSK 841 - 910 TRQIDKIQCAKTLILSLQQLFNELVQEQGPNLDRTSAHVSGIKELARRFALTFGLDQIKTREAVATLHKD 911 - 980 GIEFAFKYQNQKGQEYPPPNLAFLEVLSEFSSKLLRQDKKTVHSYLEKFLTEQMMERREDVWLPLISYRN 981 - 1050 SLVTGGEDDRMSVNSGSSSSKTSSVRNKKGRPPLHKKRVEDESLDNTWLNRTDTMIQTPGPLPAPQLTST 1051 - 1120 VLRENSRPMGDQIQEPESEHGSEPDFLHNPQMQISWLGQPKLEDLNRKDRTGMNYMKVRTGVRHAVRGLM 1121 - 1190 EEDAEPIFEDVMMSSRSQLEDMNEEFEDTMVIDLPPSRNRRERAELRPDFFDSAAIIEDDSGFGMPMF 1191 - 1258 //
| PMID | Year | Title |
|---|---|---|
| 26496610 | 2015 | A human interactome in three quantitative dimensions organized by stoichiometries and abundances. |
| 25056061 | 2014 | Biological insights from 108 schizophrenia-associated genetic loci. |
| 24390342 | 2014 | Genetics of rheumatoid arthritis contributes to biology and drug discovery. |
| 24335498 | 2014 | Mutations in the cohesin complex in acute myeloid leukemia: clinical and prognostic implications. |
| 24324008 | 2014 | Distinct functions of human cohesin-SA1 and cohesin-SA2 in double-strand break repair. |
| 23874961 | 2013 | Characterization of the interaction between the cohesin subunits Rad21 and SA1/2. |
| 23186163 | 2013 | Toward a comprehensive characterization of a human cancer cell phosphoproteome. |
| 22715410 | 2012 | Nuclear import and export signals of human cohesins SA1/STAG1 and SA2/STAG2 expressed in Saccharomyces cerevisiae. |
| 21269460 | 2011 | Initial characterization of the human central proteome. |
| 19936222 | 2009 | Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis. |
| More... |
