Property Summary

NCBI Gene PubMed Count 9
PubMed Score 6.68
PubTator Score 9.04

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (5)

Disease log2 FC p
atypical teratoid / rhabdoid tumor 1.100 0.001
medulloblastoma, large-cell 1.300 0.000
adult high grade glioma 1.800 0.000
ovarian cancer 1.300 0.000
pituitary cancer 1.300 0.003

Gene RIF (6)

PMID Text
25339026 IPP5 mutations are associated with response to paclitaxel in cervical cancer.
24935604 The data demonstrate a novel role for 8-60hIPP5(m) in the control of G2/M cell cycle progression, a process that involves the activation of ATM/p53/p21cip1/waf1/Cdc2/ cyclin B1 pathways.
22939397 The effect of IPP5 on tumor growth and the underlying molecular mechanisms were investigated by overexpression of IPP5 in HeLa cells, a human cervical carcinoma cell line.
20468071 Observational study of gene-disease association. (HuGE Navigator)
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
19874272 Overexpression of active mutant IPP5 inhibited anchorage-dependent growth and induced apoptosis in HeLa cells, which may be attributed to the up-regulation of p21, p53 and Bcl-2-antagonist/killer, and down-regulation of Bcl-2 and Bcl-X(L).

AA Sequence

MEPNSPKKIQFAVPVFQSQIAPEAAEQIRKRRPTPASLVILNEHNPPEIDDKRGPNTQGELQNASPKQRK      1 - 70
QSVYTPPTIKGVKHLKGQNESAFPEEEEGTNEREEQRDH                                    71 - 109
//

Text Mined References (13)

PMID Year Title
25339026 2014 Sensitization of cervical carcinoma cells to paclitaxel by an IPP5 active mutant.
24935604 2014 8-60hIPP5(m)-induced G2/M cell cycle arrest involves activation of ATM/p53/p21(cip1/waf1) pathways and delayed cyclin B1 nuclear translocation.
22939397 2012 IPP5, a novel inhibitor of protein phosphatase 1, suppresses tumor growth and progression of cervical carcinoma cells by inducing G2/M arrest.
20468071 2010 Evidence for genes on chromosome 2 contributing to alcohol dependence with conduct disorder and suicide attempts.
20379614 Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
19874272 2009 Effect of IPP5, a novel inhibitor of PP1, on apoptosis and the underlying mechanisms involved.
19139490 2009 A strategy for precise and large scale identification of core fucosylated glycoproteins.
18310074 2008 IPP5, a novel protein inhibitor of protein phosphatase 1, promotes G1/S progression in a Thr-40-dependent manner.
17974005 2007 The full-ORF clone resource of the German cDNA Consortium.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
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