Tbio Complexin-3

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Positively regulates a late step in synaptic vesicle exocytosis.

Property Summary

NCBI Gene PubMed Count	8
PubMed Score	26.77

PubTator Score	0.97

Knowledge Summary

Patent

No data available

TINX Plot

Disease (2)

JensenLab Experiment DistiLD
JensenLab Text Mining

Disease	Target Count	Z-score	Confidence
Essential Hypertension	94	0.0	3.0
substance-related disorder	162	0.0	1.9

Disease	Target Count	Z-score	Confidence
Chromosome 15q24 deletion syndrome	12	4.761	2.4
Acute dacryocystitis	2	4.256	2.1
Intestinal atresia	12	3.694	1.8
Hypoplastic Left Heart Syndrome	14	3.204	1.6
Cocaine Dependence	51	3.144	1.6
Myelomeningocele	16	3.078	1.5
Imperforate anus	25	3.023	1.5

Spleen 17,614

Prostate 18,213

Brain - Cerebellum 17,983

Brain - Cerebellar Hemisphere 18,015

Minor Salivary Gland 18,005

Heart - Atrial Appendage 17,896

Stomach 17,879

Adrenal Gland 18,071

Testis 18,518

Brain - Anterior cingulate cortex (BA24) 17,989

Brain - Frontal Cortex (BA9) 18,069

Brain - Amygdala 18,006

Brain - Cortex 18,039

Pituitary 18,147

Brain - Caudate (basal ganglia) 18,001

Brain - Spinal cord (cervical c-1) 17,973

Brain - Putamen (basal ganglia) 17,863

Heart - Left Ventricle 18,006

Brain - Hippocampus 18,011

Brain - Hypothalamus 18,169

Esophagus - Mucosa 18,076

Brain - Substantia nigra 17,981

Brain - Nucleus accumbens (basal ganglia... 18,024

Colon - Sigmoid 18,089

Small Intestine - Terminal Ileum 17,954

Skin - Sun Exposed (Lower leg) 17,968

Skin - Not Sun Exposed (Suprapubic) 18,081

Vagina 17,834

Lung 18,057

Whole Blood 17,439

Colon - Transverse 17,825

Ovary 17,971

Esophagus - Gastroesophageal Junction 18,000

Esophagus - Muscularis 18,017

Thyroid 18,024

Uterus 17,618

Kidney - Cortex 17,329

Breast - Mammary Tissue 18,103

Artery - Coronary 17,949

Artery - Aorta 17,896

Nerve - Tibial 18,007

Cells - EBV-transformed lymphocytes 18,186

Adipose - Visceral (Omentum) 17,937

Adipose - Subcutaneous 18,110

Liver 18,071

Artery - Tibial 17,631

Pancreas 18,123

Muscle - Skeletal 17,778

Cells - Transformed fibroblasts 17,577

Adult Retina 10,115

Adult Pancreas 9,168

NK Cells 8,475

Monocytes 7,422

Fetal Ovary 9,118

Adult Testis 10,836

Adult Ovary 10,192

Fetal Gut 8,640

CD8 Cells 9,840

Retina

adipose tissue 15,837

adrenal gland 15,963

appendix 16,247

breast 16,063

cerebral cortex 16,630

cervix, uterine 15,871

colon 15,959

duodenum 15,975

epididymis 15,863

esophagus 15,898

heart muscle 14,972

lung 16,312

lymph node 15,833

prostate 16,460

rectum 15,705

salivary gland 14,981

skin 16,206

small intestine 16,154

spleen 15,972

stomach 16,099

testis 17,936

tonsil 15,400

urinary bladder 15,814

Digestive Tract 17,369

Urinary Tract 16,678

Endocrine System 18,159

Blood and immune system 16,909

Respiratory system 16,393

Female tissues 17,400

Male tissues 17,142

Skin and soft tissues 17,230

Nervous System 16,725

Cardiovascular System 15,192

Brain 7,346

Neuroblastoma cell 187

Spleen 620

See source...

Scolopidium 48

See source...

Synonym

Accession	Q8WVH0 D3DW66 Q8TEM6 Q9H818
Symbols	CPXIII CPX-III Nbla11589

Gene

CPLX3

Ortholog (9)

Species	Source	Disease
Mouse 16,570	Inparanoid OMA EggNOG
Rat 15,117	Inparanoid OMA EggNOG
Dog 15,073	Inparanoid OMA EggNOG
Horse 14,252	Inparanoid OMA EggNOG
Cow 15,320	Inparanoid OMA EggNOG
Pig 10,168	OMA EggNOG
Opossum 12,230	Inparanoid EggNOG
Xenopus 10,468	Inparanoid OMA EggNOG
Zebrafish 9,726	Inparanoid OMA

UniProt Keyword (12)

Complete proteome 20,231

Reference proteome 20,231

Membrane 7,361

Coiled coil 2,153

Lipoprotein 825

Methylation 973

Prenylation 170

Transport 1,985

Cell junction 709

Synapse 378

See all...

GO Function (2)

syntaxin binding 69

neurotransmitter transporter activity 6

GO Component (4)

cytosol 4,834

plasma membrane 4,414

cell junction 502

presynapse 58

GO Process (3)

insulin secretion 33

regulation of neurotransmitter secretion 16

synaptic vesicle exocytosis 18

Compartment GO Term (5)

Cell junction 960

Photoreceptor ribbon synapse 13

Ribbon synapse 19

SNARE complex 72

cellular_component 18,320

MGI Phenotype (3)

vision-eye phenotype 1,622

nervous system phenotype 3,447

mortality-aging 5,018

GWAS Trait (3)

Diastolic blood pressure 144

Caffeine consumption 8

Coffee consumption 9

HCA RNA Cell Line (45)

A-431 16,131

AF22 16,160

AN3-CA 15,648

BEWO 16,726

BJ 15,448

BJ hTERT+ SV40 Large T+ 15,609

BJ hTERT+ SV40 Large T+ RasG12V 15,493

CACO-2 15,436

CAPAN-2 16,102

Daudi 15,753