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Tbio
ZFAND2B
AN1-type zinc finger protein 2B

Protein Summary
Description
Plays a role in protein homeostasis by regulating both the translocation and the ubiquitin-mediated proteasomal degradation of nascent proteins at the endoplasmic reticulum. It is involved in the regulation of signal-mediated translocation of proteins into the endoplasmic reticulum. It also plays a role in the ubiquitin-mediated proteasomal degradation of proteins for which signal-mediated translocation to the endoplasmic reticulum has failed. May therefore function in the endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (By similarity). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). This gene encodes a protein containing AN1-type zinc-fingers and ubiquitin-interacting motifs. ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000289528
  • ENSP00000289528
  • ENSG00000158552
  • ENST00000409206
  • ENSP00000386824
  • ENST00000409336
  • ENSP00000386898
  • ENST00000409594
  • ENSP00000386399
  • ENST00000444522
  • ENSP00000411334

Symbol
  • AIRAPL
  • AIRAPL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.77
transcription factor binding site profile
0.65
transcription factor
0.62
cell line
0.58
kinase perturbation
0.54


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.15   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 153   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.15   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 153   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0