Tbio NUP133 Nuclear pore complex protein Nup133

Protein Summary

Description

Involved in poly(A)+ RNA transport. The nuclear envelope creates distinct nuclear and cytoplasmic compartments in eukaryotic cells. It consists of two concentric membranes perforated by nuclear pores, large protein complexes that form aqueous channels to regulate the flow of macromolecules between the nucleus and the cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. The nucleoporin protein encoded by this gene displays evolutionarily conserved interactions with other nucleoporins. This protein, which localizes to both sides of the nuclear pore complex at interphase, remains associated with the complex during mitosis and is targeted at early stages to the reforming nuclear envelope. This protein also localizes to kinetochores of mitotic cells. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q8WUM0
• B2RAZ8
• Q5T8N0
• Q9H9W2
• Q9NV71
• Q9NVC4

Gene Name

• NUP133

Ensembl ID

• ENST00000261396
• ENSP00000261396
• ENSG00000069248

Symbol

• GAMOS8
• NPHS18
• hNUP133

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
pathway	1
cellular component	0.92
histone modification site profile	0.92
transcription factor perturbation	0.8
hub protein	0.79

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.8   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 117   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.8   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 117   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0