| Tbio | RelA-associated inhibitor |
Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis.
IASPP is one of the most evolutionarily conserved inhibitors of p53 (TP53; MIM 191170), whereas ASPP1 (MIM 606455) and ASPP2 (MIM 602143) are activators of p53.[supplied by OMIM, Mar 2008]
IASPP is one of the most evolutionarily conserved inhibitors of p53 (TP53; MIM 191170), whereas ASPP1 (MIM 606455) and ASPP2 (MIM 602143) are activators of p53.[supplied by OMIM, Mar 2008]
Comments
Property Summary
| NCBI Gene PubMed Count | 83 |
| Grant Count | 7 |
| R01 Count | 6 |
| Funding | $1,237,583.67 |
| PubMed Score | 55.12 |
| PubTator Score | 67.39 |
| Disease | log2 FC | p |
|---|---|---|
| malignant mesothelioma | 2.500 | 0.000 |
| esophageal adenocarcinoma | -1.500 | 0.030 |
| cutaneous lupus erythematosus | -1.400 | 0.014 |
| pancreatic ductal adenocarcinoma liver m... | 1.216 | 0.012 |
| colon cancer | 1.100 | 0.003 |
| active ulcerative colitis | 1.028 | 0.012 |
| interstitial cystitis | -1.900 | 0.000 |
| posterior fossa group A ependymoma | 1.200 | 0.000 |
| aldosterone-producing adenoma | -1.040 | 0.009 |
| spina bifida | -2.020 | 0.033 |
| pituitary cancer | -1.100 | 0.000 |
| PMID | Text |
|---|---|
| 27075368 | one novel region within PPP1R13L is hypomethylated in all transient neonatal diabetes type 1 patients included in this study |
| 26787707 | inhibitor of apoptosis-stimulating protein of p53 (iASPP) was identified to be a direct target of miR-140 in pancreatic duct adenocarcinoma specimens and cell lines |
| 26646590 | we show that iASPP is a novel substrate of caspases in response to apoptotic stimuli |
| 26109723 | One of the proteins identified, iASPP, showed reduced levels in the presence of GSK-3. Further, blocking iASPP activity increased cell death, particularly in p53 wild-type BC3 PEL cells. |
| 25917613 | results suggest that NFKB1 common variants and smoking duration and smoking duration-PPP1R13L rs1970764 interaction could be concerned with the lung cancer development in a Chinese population |
| 25691752 | These data demonstrate that by interacting with desmoplakin and desmin, iASPP is an important regulator of desmosomal function both in vitro and in vivo. |
| 25675294 | destabilization of p300/CBP by downregulation of iASPP expression levels appears to represent a molecular mechanism that contributes to chemoresistance in melanoma cells. |
| 25341046 | iASPP expression may act as a predictive marker of prostate cancer progression. |
| 25149434 | The present study showed that iASPP is overexpressed in oral cavity squamous cell carcinomas (OSCC)tissues and increased cytoplasmic iASPP is correlated with recurrence and poor survival outcomes in OSCC patients |
| 24997996 | data highlight the importance of 14-3-3 proteins in antiviral responses and identify RelA-associated inhibitor and sirtuin 1 as novel regulators of antiviral innate immune responses. |
| More... |
MDSEAFQSARDFLDMNFQSLAMKHMDLKQMELDTAAAKVDELTKQLESLWSDSPAPPGPQAGPPSRPPRY 1 - 70 SSSSIPEPFGSRGSPRKAATDGADTPFGRSESAPTLHPYSPLSPKGRPSSPRTPLYLQPDAYGSLDRATS 71 - 140 PRPRAFDGAGSSLGRAPSPRPGPGPLRQQGPPTPFDFLGRAGSPRGSPLAEGPQAFFPERGPSPRPPATA 141 - 210 YDAPASAFGSSLLGSGGSAFAPPLRAQDDLTLRRRPPKAWNESDLDVAYEKKPSQTASYERLDVFARPAS 211 - 280 PSLQLLPWRESSLDGLGGTGKDNLTSATLPRNYKVSPLASDRRSDAGSYRRSLGSAGPSGTLPRSWQPVS 281 - 350 RIPMPPSSPQPRGAPRQRPIPLSMIFKLQNAFWEHGASRAMLPGSPLFTRAPPPKLQPQPQPQPQPQSQP 351 - 420 QPQLPPQPQTQPQTPTPAPQHPQQTWPPVNEGPPKPPTELEPEPEIEGLLTPVLEAGDVDEGPVARPLSP 421 - 490 TRLQPALPPEAQSVPELEEVARVLAEIPRPLKRRGSMEQAPAVALPPTHKKQYQQIISRLFHRHGGPGPG 491 - 560 GPEPELSPITEGSEARAGPPAPAPPAPIPPPAPSQSSPPEQPQSMEMRSVLRKAGSPRKARRARLNPLVL 561 - 630 LLDAALTGELEVVQQAVKEMNDPSQPNEEGITALHNAICGANYSIVDFLITAGANVNSPDSHGWTPLHCA 631 - 700 ASCNDTVICMALVQHGAAIFATTLSDGATAFEKCDPYREGYADCATYLADVEQSMGLMNSGAVYALWDYS 701 - 770 AEFGDELSFREGESVTVLRRDGPEETDWWWAALHGQEGYVPRNYFGLFPRVKPQRSKV 771 - 828 //
| PMID | Year | Title |
|---|---|---|
| 27173435 | 2016 | An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. |
| 27075368 | 2016 | Genome-wide DNA methylation analysis of transient neonatal diabetes type 1 patients with mutations in ZFP57. |
| 26787707 | 2016 | MicroRNA-140 regulates cell growth and invasion in pancreatic duct adenocarcinoma by targeting iASPP. |
| 26646590 | 2015 | Caspase cleavage of iASPP potentiates its ability to inhibit p53 and NF-?B. |
| 26496610 | 2015 | A human interactome in three quantitative dimensions organized by stoichiometries and abundances. |
| 26109723 | 2015 | A Screen for Extracellular Signal-Regulated Kinase-Primed Glycogen Synthase Kinase 3 Substrates Identifies the p53 Inhibitor iASPP. |
| 25917613 | 2015 | NFKB1 common variants and PPP1R13L and CD3EAP in relation to lung cancer risk in a Chinese population. |
| 25691752 | 2015 | iASPP, a previously unidentified regulator of desmosomes, prevents arrhythmogenic right ventricular cardiomyopathy (ARVC)-induced sudden death. |
| 25675294 | 2015 | A pro-apoptotic function of iASPP by stabilizing p300 and CBP through inhibition of BRMS1 E3 ubiquitin ligase activity. |
| 25468996 | 2014 | E-cadherin interactome complexity and robustness resolved by quantitative proteomics. |
| More... |
